Seroatlas · Human Serome Atlas

EBLN1

Endogenous Bornavirus-like nucleoprotein 1

Also known as: EBLN1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0CF75
Gene
EBLN1
Ensembl
ENSG00000223601
Chromosome
10
Canonical length
366 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for EBLN1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

366 residues, UniProt reviewed canonical sequence.

>P0CF75|EBLN1
     1  MSRPRNNPQT SSPQDSTKDG SSFHYFQGRF ELSGKSRQYP ADALEPQPGI GDVKVIEKAT
    61  KSMLDPAQRS HFYLVTPSLV FLCFIFDGLH KALLSVGVSK RSNIVIGNEN KETGTLYASK
   121  FEDVLPTFTA LEMSSILRHC CDLIGIAAGS SDPICTNSLQ VQRQFKAMMI SIGRPLHSES
   181  ADLLISYNAG PAIDWINSRP WVGGLMFTFL FGEFESPACE LLDQVKVVAS KAQMMTYYTV
   241  RMFLDQCVDG STALPAVVLE IPVFEQKKPL AKKVLGDFFE FGGVLRHPVI GVLSPQMFPN
   301  LATAANYWAK RRNSTFSGFE ALDIIPGSTI TFPVLQMASA QKISRGSDMD PYTLNILRGY
   361  GISGFE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EBLN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
1.9 nTPM

Expression across tissuesHPA

Tissue

  • testis: 1.9 nTPM
  • cerebellum: 0.1 nTPM
  • lymph node: 0.1 nTPM
  • pituitary gland: 0.1 nTPM
  • retina: 0.1 nTPM
  • skeletal muscle: 0.1 nTPM

Single-cell type

  • late primary spermatocytes: 24 nCPM
  • early spermatids: 18 nCPM
  • late spermatids: 12 nCPM
  • early primary spermatocytes: 1.2 nCPM
  • undifferentiated spermatogonia: 0.9 nCPM
  • differentiating spermatogonia: 0.4 nCPM

Immune cell

  • myeloid DC: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebellum: 2.3 nTPM
  • white matter: 1.6 nTPM
  • pons: 1.4 nTPM
  • cerebral cortex: 1.3 nTPM
  • medulla oblongata: 1.3 nTPM
  • amygdala: 1.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z
1.39
DepMap mean gene effect
0.03
DepMap dependency class
none

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EBLN1 as an antibody target. Whether an autoantibody or antibody against EBLN1 could matter depends on whether native EBLN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EBLN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EBLN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EBLN1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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