Seroatlas · Human Serome Atlas

EBI3

Interleukin-27 subunit beta

Also known as: IL27B, IL27B_HUMAN, IL35B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14213
Gene
EBI3
Ensembl
ENSG00000105246
Chromosome
19
Canonical length
229 aa
Protein class
Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells. [provided by RefSeq, Sep 2008]

Canonical amino-acid sequenceUniProt

229 residues, UniProt reviewed canonical sequence.

>Q14213|EBI3
     1  MTPQLLLALV LWASCPPCSG RKGPPAALTL PRVQCRASRY PIAVDCSWTL PPAPNSTSPV
    61  SFIATYRLGM AARGHSWPCL QQTPTSTSCT ITDVQLFSMA PYVLNVTAVH PWGSSSSFVP
   121  FITEHIIKPD PPEGVRLSPL AERQLQVQWE PPGSWPFPEI FSLKYWIRYK RQGAARFHRV
   181  GPIEATSFIL RAVRPRARYY VQVAAQDLTD YGELSDWSLP ATATMSLGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EBI3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
139 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 139 nTPM
  • spleen: 33 nTPM
  • lymph node: 19 nTPM
  • appendix: 14 nTPM
  • thymus: 8.8 nTPM
  • small intestine: 8 nTPM

Single-cell type

  • extravillous trophoblasts: 974 nCPM
  • syncytiotrophoblasts: 442 nCPM
  • kupffer cells: 220 nCPM
  • migrating cytotrophoblasts: 82 nCPM
  • cdc: 72 nCPM
  • macrophages: 62 nCPM

Immune cell

  • memory B-cell: 19 nTPM
  • naive B-cell: 15 nTPM
  • non-classical monocyte: 6.4 nTPM
  • intermediate monocyte: 4.9 nTPM
  • myeloid DC: 0.8 nTPM
  • total PBMC: 0.6 nTPM

Brain region

  • white matter: 9.7 nTPM
  • thalamus: 9.1 nTPM
  • medulla oblongata: 8.8 nTPM
  • spinal cord: 6.3 nTPM
  • pons: 6 nTPM
  • cerebral cortex: 5.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.84
gnomAD pLI
0.11
gnomAD missense Z
-0.28
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EBI3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EBI3 as an antibody target. Whether an autoantibody or antibody against EBI3 could matter depends on whether native EBI3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EBI3 is annotated as secreted, so native EBI3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label EBI3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EBI3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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