Seroatlas · Human Serome Atlas

DXO

Decapping and exoribonuclease protein

Also known as: DOM3Z, DXO_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O77932
Gene: DXO
Ensembl: ENSG00000204348
Chromosome: 6
Canonical length: 396 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. The function of its protein product is unknown, but its ubiquitous expression and conservation in both simple and complex eukaryotes suggests that this may be a housekeeping gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

396 residues, UniProt reviewed canonical sequence.

>O77932|DXO
     1  MDPRGTKRGA EKTEVAEPRN KLPRPAPSLP TDPALYSGPF PFYRRPSELG CFSLDAQRQY
    61  HGDARALRYY SPPPTNGPGP NFDLRDGYPD RYQPRDEEVQ ERLDHLLCWL LEHRGRLEGG
   121  PGWLAEAIVT WRGHLTKLLT TPYERQEGWQ LAASRFQGTL YLSEVETPNA RAQRLARPPL
   181  LRELMYMGYK FEQYMCADKP GSSPDPSGEV NTNVAFCSVL RSRLGSHPLL FSGEVDCTDP
   241  QAPSTQPPTC YVELKTSKEM HSPGQWRSFY RHKLLKWWAQ SFLPGVPNVV AGFRNPDGFV
   301  SSLKTFPTMK MFEYVRNDRD GWNPSVCMNF CAAFLSFAQS TVVQDDPRLV HLFSWEPGGP
   361  VTVSVHQDAP YAFLPIWYVE AMTQDLPSPP KTPSPK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DXO can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

testis: 32 nTPM
adrenal gland: 20 nTPM
pituitary gland: 15 nTPM
ovary: 14 nTPM
liver: 13 nTPM
choroid plexus: 13 nTPM

Single-cell type

early spermatids: 502 nCPM
late spermatids: 343 nCPM
late primary spermatocytes: 177 nCPM
early primary spermatocytes: 31 nCPM
tuft cells: 23 nCPM
breast lactating cells: 21 nCPM

Immune cell

myeloid DC: 4.2 nTPM
MAIT T-cell: 3.9 nTPM
memory B-cell: 2.4 nTPM
memory CD4 T-cell: 2.3 nTPM
naive CD8 T-cell: 2.3 nTPM
gdT-cell: 2.2 nTPM

Brain region

choroid plexus: 6.2 nTPM
cerebral cortex: 5.2 nTPM
medulla oblongata: 5 nTPM
midbrain: 4.5 nTPM
pons: 4.4 nTPM
hypothalamus: 4.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.31
gnomAD pLI: 0
gnomAD missense Z: 0.91
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

5'-3' exonuclease activity
magnesium ion binding
mRNA binding
nucleotide binding
mRNA 5'-diphosphatase activity
RNA NAD+-cap (NAD+-forming) hydrolase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

RAI1-like
RAI1-like family
RAI1 like PD-(D/E)XK nuclease

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DXO as an antibody target. Whether an autoantibody or antibody against DXO could matter depends on whether native DXO is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DXO is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DXO as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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