DUSP5

Protein identityUniProt · HPA

UniProt accession

Q16690

Gene

DUSP5

Ensembl

ENSG00000138166

Chromosome

10

Canonical length

384 aa

Protein class

Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

384 residues, UniProt reviewed canonical sequence.

>Q16690|DUSP5
     1  MKVTSLDGRQ LRKMLRKEAA ARCVVLDCRP YLAFAASNVR GSLNVNLNSV VLRRARGGAV
    61  SARYVLPDEA ARARLLQEGG GGVAAVVVLD QGSRHWQKLR EESAARVVLT SLLACLPAGP
   121  RVYFLKGGYE TFYSEYPECC VDVKPISQEK IESERALISQ CGKPVVNVSY RPAYDQGGPV
   181  EILPFLYLGS AYHASKCEFL ANLHITALLN VSRRTSEACA THLHYKWIPV EDSHTADISS
   241  HFQEAIDFID CVREKGGKVL VHCEAGISRS PTICMAYLMK TKQFRLKEAF DYIKQRRSMV
   301  SPNFGFMGQL LQYESEILPS TPNPQPPSCQ GEAAGSSLIG HLQTLSPDMQ GAYCTFPASV
   361  LAPVPTHSTV SELSRSPVAT ATSC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DUSP5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.36

Highest tissue expression

164 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DUSP5.

Disease | ImmuneIEDB

Conditions an epitope on DUSP5 was assayed in.

• type 1 diabetes mellitus T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.92

gnomAD pLI

0

gnomAD missense Z

0.69

DepMap mean gene effect

0.03

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• dephosphorylation
• endoderm formation
• ERK1 and ERK2 cascade
• MAPK cascade
• negative regulation of MAPK cascade
• peptidyl-threonine dephosphorylation
• peptidyl-tyrosine dephosphorylation
• protein dephosphorylation
• signal transduction

Molecular functions

• MAP kinase tyrosine/serine/threonine phosphatase activity
• phosphatase activity
• phosphoprotein phosphatase activity
• protein serine/threonine phosphatase activity
• protein tyrosine phosphatase activity
• protein tyrosine/serine/threonine phosphatase activity

Cellular components

• cytoplasm
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Dual specificity phosphatase, catalytic domain
• Tyrosine-specific protein phosphatases domain
• Rhodanese-like domain
• Protein-tyrosine phosphatase, catalytic
• Mitogen-activated protein (MAP) kinase phosphatase
• Protein-tyrosine phosphatase, active site
• Dual specificity protein phosphatase domain
• Protein-tyrosine phosphatase-like
• Rhodanese-like domain superfamily
• Rhodanese-like domain
• Dual specificity phosphatase, catalytic domain

KeywordsUniProt

• Hydrolase
• Nucleus
• Protein phosphatase