Seroatlas · Human Serome Atlas

DUSP29

Dual specificity phosphatase 29

Also known as: DUPD1, DUS29_HUMAN, DUSP27

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q68J44
Gene: DUSP29
Ensembl: ENSG00000188716
Chromosome: 10
Canonical length: 220 aa
Protein class: Enzymes, Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables protein homodimerization activity and protein tyrosine/serine/threonine phosphatase activity. Involved in protein dephosphorylation. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

220 residues, UniProt reviewed canonical sequence.

>Q68J44|DUSP29
     1  MTSGEVKTSL KNAYSSAKRL SPKMEEEGEE EDYCTPGAFE LERLFWKGSP QYTHVNEVWP
    61  KLYIGDEATA LDRYRLQKAG FTHVLNAAHG RWNVDTGPDY YRDMDIQYHG VEADDLPTFD
   121  LSVFFYPAAA FIDRALSDDH SKILVHCVMG RSRSATLVLA YLMIHKDMTL VDAIQQVAKN
   181  RCVLPNRGFL KQLRELDKQL VQQRRRSQRQ DGEEEDGREL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DUSP29 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 97 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 97 nTPM
tongue: 13 nTPM
salivary gland: 0.9 nTPM
esophagus: 0.6 nTPM
heart muscle: 0.6 nTPM
prostate: 0.6 nTPM

Single-cell type

myonuclei: 1.1 nCPM
brain excitatory neurons: 0.1 nCPM
brain inhibitory neurons: 0.1 nCPM
distal convoluted tubule cells: 0.1 nCPM
hofbauer cells: 0.1 nCPM
other brain neurons: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 0.2 nTPM
cerebral cortex: 0.2 nTPM
hippocampal formation: 0.2 nTPM
amygdala: 0.1 nTPM
cerebellum: 0.1 nTPM
hypothalamus: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.88
gnomAD pLI: 0
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DUSP29 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PRKAA2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DUSP29 as an antibody target. Whether an autoantibody or antibody against DUSP29 could matter depends on whether native DUSP29 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DUSP29 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DUSP29 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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