Seroatlas · Human Serome Atlas

DUSP28

Dual specificity phosphatase 28

Also known as: DUS28_HUMAN, DUSP26, VHP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q4G0W2
Gene: DUSP28
Ensembl: ENSG00000188542
Chromosome: 2
Canonical length: 176 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nuclear speckles,Cytosol

OverviewNCBI Gene

Enables phosphatase activity. Involved in dephosphorylation. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

176 residues, UniProt reviewed canonical sequence.

>Q4G0W2|DUSP28
     1  MGPAEAGRRG AASPVPPPLV RVAPSLFLGS ARAAGAEEQL ARAGVTLCVN VSRQQPGPRA
    61  PGVAELRVPV FDDPAEDLLA HLEPTCAAME AAVRAGGACL VYCKNGRSRS AAVCTAYLMR
   121  HRGLSLAKAF QMVKSARPVA EPNPGFWSQL QKYEEALQAQ SCLQGEPPAL GLGPEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DUSP28 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 9.2 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 9.2 nTPM
testis: 5.9 nTPM
bone marrow: 5.1 nTPM
cerebellum: 4.4 nTPM
spleen: 4 nTPM
tongue: 3.7 nTPM

Single-cell type

cardiomyocytes: 55 nCPM
late spermatids: 53 nCPM
late primary spermatocytes: 49 nCPM
early spermatids: 40 nCPM
early primary spermatocytes: 36 nCPM
platelets: 35 nCPM

Immune cell

basophil: 8.8 nTPM
naive B-cell: 1.8 nTPM
neutrophil: 1.8 nTPM
plasmacytoid DC: 1.8 nTPM
NK-cell: 1.5 nTPM
MAIT T-cell: 1.4 nTPM

Brain region

cerebellum: 11 nTPM
white matter: 8.7 nTPM
medulla oblongata: 8.4 nTPM
cerebral cortex: 8.3 nTPM
hypothalamus: 8.3 nTPM
basal ganglia: 8.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.62
gnomAD pLI: 0.18
gnomAD missense Z: -1.05
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

dephosphorylation

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DUSP28 as an antibody target. Whether an autoantibody or antibody against DUSP28 could matter depends on whether native DUSP28 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DUSP28 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DUSP28 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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