DUSP26

Protein identityUniProt · HPA

UniProt accession

Q9BV47

Gene

DUSP26

Ensembl

ENSG00000133878

Chromosome

8

Canonical length

211 aa

Protein class

Enzymes, Predicted intracellular proteins

Subcellular location

Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the tyrosine phosphatase family of proteins and exhibits dual specificity by dephosphorylating tyrosine as well as serine and threonine residues. This gene has been described as both a tumor suppressor and an oncogene depending on the cellular context. This protein may regulate neuronal proliferation and has been implicated in the progression of glioblastoma through its ability to dephosphorylate the p53 tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Canonical amino-acid sequenceUniProt

211 residues, UniProt reviewed canonical sequence.

>Q9BV47|DUSP26
     1  MCPGNWLWAS MTFMARFSRS SSRSPVRTRG TLEEMPTVQH PFLNVFELER LLYTGKTACN
    61  HADEVWPGLY LGDQDMANNR RELRRLGITH VLNASHSRWR GTPEAYEGLG IRYLGVEAHD
   121  SPAFDMSIHF QTAADFIHRA LSQPGGKILV HCAVGVSRSA TLVLAYLMLY HHLTLVEAIK
   181  KVKDHRGIIP NRGFLRQLLA LDRRLRQGLE A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DUSP26 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.35

Highest tissue expression

395 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.23

gnomAD pLI

0

gnomAD missense Z

1.21

DepMap mean gene effect

0.04

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• negative regulation of ERK1 and ERK2 cascade
• negative regulation of MAPK cascade
• negative regulation of transcription by RNA polymerase II
• positive regulation of cell adhesion
• protein dephosphorylation

Molecular functions

• MAP kinase phosphatase activity
• p53 binding
• phosphoprotein phosphatase activity
• protein serine/threonine phosphatase activity
• protein tyrosine phosphatase activity
• protein tyrosine/serine/threonine phosphatase activity
• RNA polymerase II-specific DNA-binding transcription factor binding

Cellular components

• cytoplasm
• extracellular exosome
• Golgi apparatus
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Dual specificity phosphatase, catalytic domain
• Tyrosine-specific protein phosphatases domain
• Protein-tyrosine phosphatase, active site
• Atypical dual specificity phosphatase, subfamily A
• Dual specificity protein phosphatase domain
• Protein-tyrosine phosphatase-like
• Dual specificity phosphatase, catalytic domain

KeywordsUniProt

• Cytoplasm
• Golgi apparatus
• Hydrolase
• Nucleus
• Protein phosphatase

InteractionsUniProt · HPA

Protein binding partners of DUSP26 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• HSF4