Seroatlas · Human Serome Atlas

DUSP23

Dual specificity protein phosphatase 23

Also known as: DUS23_HUMAN, DUSP25, FLJ20442

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BVJ7
Gene: DUSP23
Ensembl: ENSG00000158716
Chromosome: 1
Canonical length: 150 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables protein tyrosine/serine/threonine phosphatase activity. Involved in dephosphorylation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

150 residues, UniProt reviewed canonical sequence.

>Q9BVJ7|DUSP23
     1  MGVQPPNFSW VLPGRLAGLA LPRLPAHYQF LLDLGVRHLV SLTERGPPHS DSCPGLTLHR
    61  LRIPDFCPPA PDQIDRFVQI VDEANARGEA VGVHCALGFG RTGTMLACYL VKERGLAAGD
   121  AIAEIRRLRP GSIETYEQEK AVFQFYQRTK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DUSP23 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 183 nTPM

Expression across tissuesHPA

Tissue

kidney: 183 nTPM
liver: 172 nTPM
salivary gland: 144 nTPM
adrenal gland: 114 nTPM
breast: 93 nTPM
esophagus: 78 nTPM

Single-cell type

oocytes: 327 nCPM
submucosal glandular cells: 292 nCPM
salivary acinar cells: 280 nCPM
hepatocytes: 261 nCPM
esophageal suprabasal cells: 257 nCPM
epididymal efferent duct absorptive cells: 250 nCPM

Immune cell

myeloid DC: 262 nTPM
eosinophil: 230 nTPM
neutrophil: 187 nTPM
classical monocyte: 182 nTPM
intermediate monocyte: 154 nTPM
basophil: 113 nTPM

Brain region

spinal cord: 25 nTPM
medulla oblongata: 23 nTPM
pons: 23 nTPM
cerebellum: 23 nTPM
hippocampal formation: 22 nTPM
hypothalamus: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.69
gnomAD pLI: 0
gnomAD missense Z: 0.3
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DUSP23 as an antibody target. Whether an autoantibody or antibody against DUSP23 could matter depends on whether native DUSP23 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DUSP23 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DUSP23 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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