Seroatlas · Human Serome Atlas

DUSP22

Dual specificity protein phosphatase 22

Also known as: DUS22_HUMAN, JKAP, JSP1, MKPX, VHX

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NRW4
Gene
DUSP22
Ensembl
ENSG00000112679
Chromosome
6
Canonical length
184 aa
Protein class
Enzymes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles

OverviewNCBI Gene

Enables phosphoprotein phosphatase activity; protein tyrosine kinase binding activity; and protein tyrosine kinase inhibitor activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; negative regulation of T cell receptor signaling pathway; and negative regulation of focal adhesion assembly. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in cytoplasm; leading edge of lamellipodium; and plasma membrane. Part of filamentous actin. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

184 residues, UniProt reviewed canonical sequence.

>Q9NRW4|DUSP22
     1  MGNGMNKILP GLYIGNFKDA RDAEQLSKNK VTHILSVHDS ARPMLEGVKY LCIPAADSPS
    61  QNLTRHFKES IKFIHECRLR GESCLVHCLA GVSRSVTLVI AYIMTVTDFG WEDALHTVRA
   121  GRSCANPNVG FQRQLQEFEK HEVHQYRQWL KEEYGESPLQ DAEEAKNILA APGILKFWAF
   181  LRRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DUSP22 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
50 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 50 nTPM
  • colon: 45 nTPM
  • esophagus: 44 nTPM
  • testis: 42 nTPM
  • spleen: 42 nTPM
  • heart muscle: 40 nTPM

Single-cell type

  • esophageal apical cells: 285 nCPM
  • oocytes: 216 nCPM
  • esophageal suprabasal cells: 177 nCPM
  • megakaryocytes: 124 nCPM
  • platelets: 106 nCPM
  • plasma cells: 98 nCPM

Immune cell

  • memory B-cell: 41 nTPM
  • basophil: 37 nTPM
  • myeloid DC: 34 nTPM
  • naive B-cell: 34 nTPM
  • classical monocyte: 33 nTPM
  • plasmacytoid DC: 29 nTPM

Brain region

  • white matter: 75 nTPM
  • medulla oblongata: 58 nTPM
  • cerebral cortex: 57 nTPM
  • pons: 52 nTPM
  • thalamus: 50 nTPM
  • basal ganglia: 49 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.93
gnomAD pLI
0.01
gnomAD missense Z
0.45
DepMap mean gene effect
-0.18
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DUSP22 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DUSP22 as an antibody target. Whether an autoantibody or antibody against DUSP22 could matter depends on whether native DUSP22 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DUSP22 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DUSP22 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DUSP22. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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