Seroatlas · Human Serome Atlas

DUSP21

Dual specificity protein phosphatase 21

Also known as: DUS21_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H596
Gene: DUSP21
Ensembl: ENSG00000189037
Chromosome: X
Canonical length: 190 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoli,Centrosome,Connecting piece,Mid piece,Principal piece

OverviewNCBI Gene

This gene encodes a member of the dual specificity phosphatase family, specifically the low molecular weight dual specificity phosphatase family. The encoded protein localizes to both the cytoplasm and the nucleus and functions to remove phosphate groups from phosphotyrosine and phosphothreonine residues.[provided by RefSeq, Mar 2009]

Canonical amino-acid sequenceUniProt

190 residues, UniProt reviewed canonical sequence.

>Q9H596|DUSP21
     1  MTASASSFSS SQGVQQPSIY SFSQITRSLF LSNGVAANDK LLLSSNRITA IVNASVEVVN
    61  VFFEGIQYIK VPVTDARDSR LYDFFDPIAD LIHTIDMRQG RTLLHCMAGV SRSASLCLAY
   121  LMKYHSMSLL DAHTWTKSRR PIIRPNNGFW EQLINYEFKL FNNNTVRMIN SPVGNIPDIY
   181  EKDLRMMISM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DUSP21 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

testis: 10 nTPM
bone marrow: 0.2 nTPM
small intestine: 0.2 nTPM
colon: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

late spermatids: 519 nCPM
early spermatids: 96 nCPM
late primary spermatocytes: 23 nCPM
early primary spermatocytes: 0.8 nCPM
leydig cells: 0.5 nCPM
t-cells: 0.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.96
gnomAD pLI: 0
gnomAD missense Z: 0.52
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DUSP21 as an antibody target. Whether an autoantibody or antibody against DUSP21 could matter depends on whether native DUSP21 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DUSP21 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DUSP21 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...