DUSP19

Protein identityUniProt · HPA

UniProt accession

Q8WTR2

Gene

DUSP19

Ensembl

ENSG00000162999

Chromosome

2

Canonical length

217 aa

Protein class

Enzymes, Predicted intracellular proteins

Subcellular location

Nucleoplasm

OverviewNCBI Gene

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

Canonical amino-acid sequenceUniProt

217 residues, UniProt reviewed canonical sequence.

>Q8WTR2|DUSP19
     1  MYSLNQEIKA FSRNNLRKQC TRVTTLTGKK IIETWKDARI HVVEEVEPSS GGGCGYVQDL
    61  SSDLQVGVIK PWLLLGSQDA AHDLDTLKKN KVTHILNVAY GVENAFLSDF TYKSISILDL
   121  PETNILSYFP ECFEFIEEAK RKDGVVLVHC NAGVSRAAAI VIGFLMNSEQ TSFTSAFSLV
   181  KNARPSICPN SGFMEQLRTY QEGKESNKCD RIQENSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DUSP19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.35

Highest tissue expression

3.7 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.24

gnomAD pLI

0.01

gnomAD missense Z

-0.09

DepMap mean gene effect

0

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• negative regulation of JNK cascade
• positive regulation of JNK cascade
• positive regulation of MAPK cascade
• regulation of JNK cascade

Molecular functions

• MAP-kinase scaffold activity
• mitogen-activated protein kinase kinase kinase binding
• protein kinase activator activity
• protein kinase inhibitor activity
• protein serine/threonine phosphatase activity
• protein tyrosine phosphatase activity
• protein tyrosine/serine/threonine phosphatase activity
• JUN kinase phosphatase activity

Cellular components

• cytoplasm

Protein domainsUniProt · Pfam · InterPro

• Dual specificity phosphatase, catalytic domain
• Tyrosine-specific protein phosphatases domain
• Dual specificity protein phosphatase domain
• Protein-tyrosine phosphatase-like
• Dual specificity phosphatase, catalytic domain

KeywordsUniProt

• Acetylation
• Hydrolase
• Protein phosphatase

InteractionsUniProt · HPA

Protein binding partners of DUSP19 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ALAS1