Seroatlas · Human Serome Atlas

DUSP15

Dual specificity protein phosphatase 15

Also known as: bA243J16.5, bA243J16.6, C20orf57, DUS15_HUMAN, FLJ20645, VHY

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H1R2
Gene: DUSP15
Ensembl: ENSG00000149599
Chromosome: 20
Canonical length: 295 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this gene has both protein-tyrosine phophatase activity and serine/threonine-specific phosphatase activity, and therefore is known as a dual specificity phosphatase. This protein may function in the differentiation of oligodendrocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

295 residues, UniProt reviewed canonical sequence.

>Q9H1R2|DUSP15
     1  MTEGVLPGLY LGNFIDAKDL DQLGRNKITH IISIHESPQP LLQDITYLRI PVADTPEVPI
    61  KKHFKECINF IHCCRLNGGN CLVHCFAGIS RSTTIVTAYV MTVTGLGWRD VLEAIKATRP
   121  IANPNPGFRQ QLEEFGWASS QKGARHRTSK TSGAQCPPMT SATCLLAARV ALLSAALVRE
   181  ATGRTAQRCR LSPRAAAERL LGPPPHVAAG WSPDPKYQIC LCFGEEDPGP TQHPKEQLIM
   241  ADVQVQLRPG SSSCTLSAST ERPDGSSTPG NPDGITHLQC SCLHPKRAAS SSCTR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DUSP15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 209 nTPM

Expression across tissuesHPA

Tissue

testis: 209 nTPM
kidney: 49 nTPM
spinal cord: 19 nTPM
midbrain: 18 nTPM
basal ganglia: 13 nTPM
parathyroid gland: 13 nTPM

Single-cell type

late spermatids: 1,777 nCPM
late primary spermatocytes: 365 nCPM
early spermatids: 277 nCPM
epididymal principal cells: 65 nCPM
epididymal clear cells: 51 nCPM
sertoli cells: 38 nCPM

Immune cell

naive B-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

medulla oblongata: 37 nTPM
cerebellum: 24 nTPM
midbrain: 19 nTPM
white matter: 18 nTPM
pons: 18 nTPM
spinal cord: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.5
gnomAD pLI: 0
gnomAD missense Z: -0.4
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DUSP15 as an antibody target. Whether an autoantibody or antibody against DUSP15 could matter depends on whether native DUSP15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DUSP15 is annotated at the cell surface, where native DUSP15 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label DUSP15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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