DUSP14

Protein identityUniProt · HPA

UniProt accession

O95147

Gene

DUSP14

Ensembl

ENSG00000276023

Chromosome

17

Canonical length

198 aa

Protein class

Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cytosol

OverviewNCBI Gene

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

Canonical amino-acid sequenceUniProt

198 residues, UniProt reviewed canonical sequence.

>O95147|DUSP14
     1  MSSRGHSTLP RTLMAPRMIS EGDIGGIAQI TSSLFLGRGS VASNRHLLQA RGITCIVNAT
    61  IEIPNFNWPQ FEYVKVPLAD MPHAPIGLYF DTVADKIHSV SRKHGATLVH CAAGVSRSAT
   121  LCIAYLMKFH NVCLLEAYNW VKARRPVIRP NVGFWRQLID YERQLFGKST VKMVQTPYGI
   181  VPDVYEKESR HLMPYWGI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DUSP14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.3

Highest tissue expression

45 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.17

gnomAD pLI

0.12

gnomAD missense Z

1.45

DepMap mean gene effect

-0.14

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

• MAP kinase tyrosine/serine/threonine phosphatase activity
• protein serine/threonine phosphatase activity
• protein tyrosine phosphatase activity
• RNA binding

Cellular components

• cytoplasm

Protein domainsUniProt · Pfam · InterPro

• Dual specificity phosphatase, catalytic domain
• Tyrosine-specific protein phosphatases domain
• Protein-tyrosine phosphatase, active site
• Atypical dual specificity phosphatase, subfamily B
• Dual specificity protein phosphatase domain
• Protein-tyrosine phosphatase-like
• Dual Specificity Protein Phosphatases
• Dual specificity phosphatase, catalytic domain

KeywordsUniProt

• Hydrolase
• Protein phosphatase

InteractionsUniProt · HPA

Protein binding partners of DUSP14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CD28