Seroatlas · Human Serome Atlas

DUSP13B

Dual specificity protein phosphatase 13B

Also known as: BEDP, DS13B_HUMAN, DUSP13, DUSP13A, FLJ32450, MDSP, TMDP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UII6
Gene: DUSP13B
Ensembl: ENSG00000079393
Chromosome: 10
Canonical length: 198 aa
Protein class: Enzymes, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Members of the protein-tyrosine phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation. This gene encodes a dual specificity phosphatase that acts on both phosphotyrosine and phosphoserine/threonine residues. The encoded protein is expressed in testis. [provided by RefSeq, Mar 2023]

Canonical amino-acid sequenceUniProt

198 residues, UniProt reviewed canonical sequence.

>Q9UII6|DUSP13B
     1  MDSLQKQDLR RPKIHGAVQA SPYQPPTLAS LQRLLWVRQA ATLNHIDEVW PSLFLGDAYA
    61  ARDKSKLIQL GITHVVNAAA GKFQVDTGAK FYRGMSLEYY GIEADDNPFF DLSVYFLPVA
   121  RYIRAALSVP QGRVLVHCAM GVSRSATLVL AFLMICENMT LVEAIQTVQA HRNICPNSGF
   181  LRQLQVLDNR LGRETGRF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DUSP13B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 241 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 241 nTPM
tongue: 104 nTPM
testis: 51 nTPM
heart muscle: 15 nTPM
bone marrow: 5.6 nTPM
esophagus: 3.2 nTPM

Single-cell type

early spermatids: 442 nCPM
late primary spermatocytes: 266 nCPM
myonuclei: 141 nCPM
late spermatids: 83 nCPM
thymic myoid cells: 35 nCPM
neutrophil progenitors: 20 nCPM

Immune cell

neutrophil: 1.4 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

pons: 3.2 nTPM
midbrain: 0.9 nTPM
hypothalamus: 0.5 nTPM
cerebral cortex: 0.4 nTPM
basal ganglia: 0.2 nTPM
medulla oblongata: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.29
gnomAD pLI: 0
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DUSP13B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

LMNA

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DUSP13B as an antibody target. Whether an autoantibody or antibody against DUSP13B could matter depends on whether native DUSP13B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DUSP13B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DUSP13B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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