Seroatlas · Human Serome Atlas

DUSP12

Dual specificity protein phosphatase 12

Also known as: DUS12_HUMAN, DUSP1, YVH1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UNI6
Gene
DUSP12
Ensembl
ENSG00000081721
Chromosome
1
Canonical length
340 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

340 residues, UniProt reviewed canonical sequence.

>Q9UNI6|DUSP12
     1  MLEAPGPSDG CELSNPSASR VSCAGQMLEV QPGLYFGGAA AVAEPDHLRE AGITAVLTVD
    61  SEEPSFKAGP GVEDLWRLFV PALDKPETDL LSHLDRCVAF IGQARAEGRA VLVHCHAGVS
   121  RSVAIITAFL MKTDQLPFEK AYEKLQILKP EAKMNEGFEW QLKLYQAMGY EVDTSSAIYK
   181  QYRLQKVTEK YPELQNLPQE LFAVDPTTVS QGLKDEVLYK CRKCRRSLFR SSSILDHREG
   241  SGPIAFAHKR MTPSSMLTTG RQAQCTSYFI EPVQWMESAL LGVMDGQLLC PKCSAKLGSF
   301  NWYGEQCSCG RWITPAFQIH KNRVDEMKIL PVLGSQTGKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DUSP12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
29 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 29 nTPM
  • cerebellum: 18 nTPM
  • ovary: 14 nTPM
  • breast: 13 nTPM
  • endometrium: 13 nTPM
  • lymph node: 13 nTPM

Single-cell type

  • gastric progenitor cells: 36 nCPM
  • tuft cells: 35 nCPM
  • parietal cells: 32 nCPM
  • esophageal basal cells: 31 nCPM
  • extravillous trophoblasts: 31 nCPM
  • granulosa cells: 29 nCPM

Immune cell

  • basophil: 32 nTPM
  • NK-cell: 29 nTPM
  • MAIT T-cell: 23 nTPM
  • myeloid DC: 22 nTPM
  • naive CD8 T-cell: 22 nTPM
  • memory CD4 T-cell: 21 nTPM

Brain region

  • cerebellum: 9.8 nTPM
  • white matter: 7.3 nTPM
  • cerebral cortex: 6 nTPM
  • hypothalamus: 6 nTPM
  • basal ganglia: 5.8 nTPM
  • spinal cord: 5.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DUSP12.

Disease | ImmuneIEDB

Conditions an epitope on DUSP12 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.89
gnomAD pLI
0
gnomAD missense Z
0.58
DepMap mean gene effect
-0.22
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DUSP12 as an antibody target. Whether an autoantibody or antibody against DUSP12 could matter depends on whether native DUSP12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DUSP12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DUSP12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DUSP12. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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