Seroatlas · Human Serome Atlas

DUSP11

RNA/RNP complex-1-interacting phosphatase

Also known as: DUS11_HUMAN, PIR1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75319
Gene
DUSP11
Ensembl
ENSG00000144048
Chromosome
2
Canonical length
330 aa
Protein class
Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli fibrillar center,Cytokinetic bridge

OverviewNCBI Gene

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism. [provided by RefSeq, Sep 2008]

Canonical amino-acid sequenceUniProt

330 residues, UniProt reviewed canonical sequence.

>O75319|DUSP11
     1  MSQWHHPRSG WGRRRDFSGR SSAKKKGGNH IPERWKDYLP VGQRMPGTRF IAFKVPLQKS
    61  FEKKLAPEEC FSPLDLFNKI REQNEELGLI IDLTYTQRYY KPEDLPETVP YLKIFTVGHQ
   121  VPDDETIFKF KHAVNGFLKE NKDNDKLIGV HCTHGLNRTG YLICRYLIDV EGVRPDDAIE
   181  LFNRCRGHCL ERQNYIEDLQ NGPIRKNWNS SVPRSSDFED SAHLMQPVHN KPVKQGPRYN
   241  LHQIQGHSAP RHFHTQTQSL QQSVRKFSEN PHVYQRHHLP PPGPPGEDYS HRRYSWNVKP
   301  NASRAAQDRR RWYPYNYSRL SYPACWEWTQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DUSP11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
38 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 38 nTPM
  • bone marrow: 33 nTPM
  • esophagus: 29 nTPM
  • ovary: 27 nTPM
  • skin: 26 nTPM
  • tonsil: 25 nTPM

Single-cell type

  • esophageal apical cells: 218 nCPM
  • oocytes: 124 nCPM
  • epididymal efferent duct absorptive cells: 91 nCPM
  • esophageal suprabasal cells: 86 nCPM
  • fallopian secretory cells: 79 nCPM
  • suprabasal keratinocytes: 76 nCPM

Immune cell

  • eosinophil: 101 nTPM
  • T-reg: 92 nTPM
  • basophil: 77 nTPM
  • MAIT T-cell: 75 nTPM
  • total PBMC: 74 nTPM
  • naive CD4 T-cell: 72 nTPM

Brain region

  • cerebellum: 24 nTPM
  • choroid plexus: 24 nTPM
  • cerebral cortex: 22 nTPM
  • basal ganglia: 21 nTPM
  • white matter: 21 nTPM
  • hypothalamus: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.09
gnomAD pLI
0
gnomAD missense Z
0.42

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DUSP11 as an antibody target. Whether an autoantibody or antibody against DUSP11 could matter depends on whether native DUSP11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DUSP11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DUSP11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DUSP11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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