Seroatlas · Human Serome Atlas

DUS1L

tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like

Also known as: DUS1, DUS1L_HUMAN, PP3111

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6P1R4
Gene
DUS1L
Ensembl
ENSG00000169718
Chromosome
17
Canonical length
473 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Plasma membrane

OverviewNCBI Gene

Enables tRNA-dihydrouridine16 synthase activity and tRNA-dihydrouridine17 synthase activity. Involved in tRNA dihydrouridine synthesis. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

473 residues, UniProt reviewed canonical sequence.

>Q6P1R4|DUS1L
     1  MPKLQGFEFW SRTLRGARHV VAPMVDQSEL AWRLLSRRHG AQLCYTPMLH AQVFVRDANY
    61  RKENLYCEVC PEDRPLIVQF CANDPEVFVQ AALLAQDYCD AIDLNLGCPQ MIAKRGHYGA
   121  FLQDEWDLLQ RMILLAHEKL SVPVTCKIRV FPEIDKTVRY AQMLEKAGCQ LLTVHGRTKE
   181  QKGPLSGAAS WEHIKAVRKA VAIPVFANGN IQCLQDVERC LRDTGVQGVM SAEGNLHNPA
   241  LFEGRSPAVW ELAEEYLDIV REHPCPLSYV RAHLFKLWHH TLQVHQELRE ELAKVKTLEG
   301  IAAVSQELKL RCQEEISRQE GAKPTGDLPF HWICQPYIRP GPREGSKEKA GARSKRALEE
   361  EEGGTEVLSK NKQKKQLRNP HKTFDPSLKP KYAKCDQCGN PKGNRCVFSL CRGCCKKRAS
   421  KETADCPGHG LLFKTKLEKS LAWKEAQPEL QEPQPAAPGT PGGFSEVMGS ALA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DUS1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
171 nTPM

Expression across tissuesHPA

Tissue

  • liver: 171 nTPM
  • pancreas: 146 nTPM
  • skeletal muscle: 140 nTPM
  • spleen: 128 nTPM
  • skin: 123 nTPM
  • stomach: 117 nTPM

Single-cell type

  • late spermatids: 228 nCPM
  • breast lactating cells: 155 nCPM
  • late primary spermatocytes: 99 nCPM
  • hepatocytes: 96 nCPM
  • early spermatids: 78 nCPM
  • breast secretory cells: 77 nCPM

Immune cell

  • plasmacytoid DC: 7.9 nTPM
  • T-reg: 7.7 nTPM
  • naive CD4 T-cell: 6.6 nTPM
  • MAIT T-cell: 6 nTPM
  • NK-cell: 6 nTPM
  • naive CD8 T-cell: 5.6 nTPM

Brain region

  • cerebral cortex: 44 nTPM
  • choroid plexus: 43 nTPM
  • medulla oblongata: 43 nTPM
  • thalamus: 40 nTPM
  • hippocampal formation: 38 nTPM
  • white matter: 38 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DUS1L.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 94 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.97
gnomAD pLI
0
gnomAD missense Z
0.85
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DUS1L as an antibody target. Whether an autoantibody or antibody against DUS1L could matter depends on whether native DUS1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DUS1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DUS1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DUS1L. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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