Seroatlas · Human Serome Atlas

DTWD2

tRNA-uridine aminocarboxypropyltransferase 2

Also known as: DTWD2_HUMAN, FLJ33977

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NBA8
Gene: DTWD2
Ensembl: ENSG00000169570
Chromosome: 5
Canonical length: 298 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nuclear bodies

OverviewNCBI Gene

Enables tRNA-uridine aminocarboxypropyltransferase activity. Involved in RNA glycosylation and tRNA modification. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

298 residues, UniProt reviewed canonical sequence.

>Q8NBA8|DTWD2
     1  MESQKEARTL QEPVARPSGA SSSQTPNDKE RREGGAVPAA AALGAEADDD SADGLWELPV
    61  EPAERRPECT RCSRPQKVCL CPFLPAHPLH ISTHLYIIQH PAEENKVLRT VPLLAACLPQ
   121  DKCKVKIGRR FSEERDPELS TVCRKSGTLI LYPGAEAANL EEFILDSPVY PSTIIIIDGT
   181  WSQAKDIFYK NSLFRHPKQV QLKTSISSQY VIRMQPTNRC LSTLECAAVA LSILEKNNYI
   241  QETLLRPLQA LCSFQLQHGA QIRLSKEHLL KNGLYPKPMP KNKRKLRKME LLMNSVKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DTWD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 9.8 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 9.8 nTPM
thyroid gland: 8.4 nTPM
heart muscle: 6.1 nTPM
kidney: 6 nTPM
tongue: 5.9 nTPM
cervix: 4.7 nTPM

Single-cell type

cardiomyocytes: 214 nCPM
myonuclei: 212 nCPM
epicardial cells: 114 nCPM
choroid plexus epithelial cells: 93 nCPM
distal convoluted tubule cells: 82 nCPM
oligodendrocyte progenitor cells: 79 nCPM

Immune cell

basophil: 0.9 nTPM
naive B-cell: 0.6 nTPM
neutrophil: 0.6 nTPM
NK-cell: 0.5 nTPM
plasmacytoid DC: 0.5 nTPM
memory B-cell: 0.4 nTPM

Brain region

cerebellum: 9.7 nTPM
choroid plexus: 9.5 nTPM
cerebral cortex: 8.4 nTPM
midbrain: 7.9 nTPM
thalamus: 7.7 nTPM
white matter: 7.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.61
gnomAD pLI: 0
gnomAD missense Z: -1.37
DepMap mean gene effect: 0.13
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

tRNA modification
glycoRNA biosynthetic process

Molecular functions

tRNA-uridine aminocarboxypropyltransferase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

DTW
DTW domain
DTW domain-containing protein DTWD2/TAPT

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DTWD2 as an antibody target. Whether an autoantibody or antibody against DTWD2 could matter depends on whether native DTWD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DTWD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DTWD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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