Seroatlas · Human Serome Atlas

DTWD1

tRNA-uridine aminocarboxypropyltransferase 1

Also known as: DTWD1_HUMAN, MDS009, MGC111207

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N5C7
Gene: DTWD1
Ensembl: ENSG00000104047
Chromosome: 15
Canonical length: 304 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli rim,Mitotic chromosome,Vesicles

OverviewNCBI Gene

Enables tRNA-uridine aminocarboxypropyltransferase activity. Involved in tRNA modification. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

304 residues, UniProt reviewed canonical sequence.

>Q8N5C7|DTWD1
     1  MSLNPPIFLK RSEENSSKFV ETKQSQTTSI ASEDPLQNLC LASQEVLQKA QQSGRSKCLK
    61  CGGSRMFYCY TCYVPVENVP IEQIPLVKLP LKIDIIKHPN ETDGKSTAIH AKLLAPEFVN
   121  IYTYPCIPEY EEKDHEVALI FPGPQSISIK DISFHLQKRI QNNVRGKNDD PDKPSFKRKR
   181  TEEQEFCDLN DSKCKGTTLK KIIFIDSTWN QTNKIFTDER LQGLLQVELK TRKTCFWRHQ
   241  KGKPDTFLST IEAIYYFLVD YHTDILKEKY RGQYDNLLFF YSFMYQLIKN AKCSGDKETG
   301  KLTH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DTWD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

pancreas: 31 nTPM
cervix: 25 nTPM
ovary: 22 nTPM
gallbladder: 22 nTPM
endometrium: 21 nTPM
salivary gland: 20 nTPM

Single-cell type

pancreatic acinar cells: 160 nCPM
fibro-adipogenic progenitors: 117 nCPM
decidual stromal cells: 111 nCPM
medullary thymic epithelial cells: 110 nCPM
smooth muscle cells: 104 nCPM
brain excitatory neurons: 101 nCPM

Immune cell

plasmacytoid DC: 25 nTPM
non-classical monocyte: 15 nTPM
NK-cell: 14 nTPM
myeloid DC: 13 nTPM
naive CD4 T-cell: 12 nTPM
intermediate monocyte: 12 nTPM

Brain region

basal ganglia: 25 nTPM
hypothalamus: 24 nTPM
white matter: 24 nTPM
hippocampal formation: 23 nTPM
cerebral cortex: 23 nTPM
cerebellum: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.68
gnomAD pLI: 0
gnomAD missense Z: -0.05
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DTWD1 as an antibody target. Whether an autoantibody or antibody against DTWD1 could matter depends on whether native DTWD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DTWD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DTWD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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