Seroatlas · Human Serome Atlas

DTD2

D-aminoacyl-tRNA deacylase 2

Also known as: C14orf126, DTD2_HUMAN, MGC9912

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96FN9
Gene: DTD2
Ensembl: ENSG00000129480
Chromosome: 14
Canonical length: 168 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Vesicles
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables Ala-tRNA(Thr) deacylase activity. Involved in aminoacyl-tRNA metabolism involved in translational fidelity. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

168 residues, UniProt reviewed canonical sequence.

>Q96FN9|DTD2
     1  MAEGSRIPQA RALLQQCLHA RLQIRPADGD VAAQWVEVQR GLVIYVCFFK GADKELLPKM
    61  VNTLLNVKLS ETENGKHVSI LDLPGNILII PQATLGGRLK GRNMQYHSNS GKEEGFELYS
   121  QFVTLCEKEV AANSKCAEAR VVVEHGTYGN RQVLKLDTNG PFTHLIEF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DTD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 8.1 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 8.1 nTPM
liver: 7.7 nTPM
breast: 6.7 nTPM
midbrain: 6.4 nTPM
hippocampal formation: 6.2 nTPM
cerebral cortex: 6.1 nTPM

Single-cell type

late spermatids: 7.7 nCPM
late primary spermatocytes: 7.4 nCPM
early spermatids: 3.9 nCPM
fallopian tube ciliated cells: 3 nCPM
megakaryocyte progenitors: 3 nCPM
platelets: 2.8 nCPM

Immune cell

naive CD4 T-cell: 4.5 nTPM
myeloid DC: 3.7 nTPM
NK-cell: 3.7 nTPM
naive B-cell: 3.2 nTPM
memory CD4 T-cell: 2.9 nTPM
naive CD8 T-cell: 2.9 nTPM

Brain region

white matter: 19 nTPM
basal ganglia: 17 nTPM
thalamus: 16 nTPM
midbrain: 16 nTPM
pons: 16 nTPM
cerebral cortex: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.66
gnomAD pLI: 0
gnomAD missense Z: 0.76
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

tRNA metabolic process
aminoacyl-tRNA metabolism involved in translational fidelity

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DTD2 as an antibody target. Whether an autoantibody or antibody against DTD2 could matter depends on whether native DTD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DTD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DTD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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