DSTYK

Protein identityUniProt · HPA

UniProt accession

Q6XUX3

Gene

DSTYK

Ensembl

ENSG00000133059

Chromosome

1

Canonical length

929 aa

Protein class

Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a dual serine/threonine and tyrosine protein kinase which is expressed in multiple tissues. It is thought to function as a regulator of cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Canonical amino-acid sequenceUniProt

929 residues, UniProt reviewed canonical sequence.

>Q6XUX3|DSTYK
     1  MEGDGVPWGS EPVSGPGPGG GGMIRELCRG FGRYRRYLGR LRQNLRETQK FFRDIKCSHN
    61  HTCLSSLTGG GGAERGPAGD VAETGLQAGQ LSCISFPPKE EKYLQQIVDC LPCILILGQD
   121  CNVKCQLLNL LLGVQVLPTT KLGSEESCKL RRLRFTYGTQ TRVSLALPGQ YELVHTLVAH
   181  QGNWETIPEE DLEVQENNED AAHVLAELEV TMHHALLQEV DVVVAPCQGL RPTVDVLGDL
   241  VNDFLPVITY ALHKDELSER DEQELQEIRK YFSFPVFFFK VPKLGSEIID SSTRRMESER
   301  SPLYRQLIDL GYLSSSHWNC GAPGQDTKAQ SMLVEQSEKL RHLSTFSHQV LQTRLVDAAK
   361  ALNLVHCHCL DIFINQAFDM QRDLQITPKR LEYTRKKENE LYESLMNIAN RKQEEMKDMI
   421  VETLNTMKEE LLDDATNMEF KDVIVPENGE PVGTREIKCC IRQIQELIIS RLNQAVANKL
   481  ISSVDYLRES FVGTLERCLQ SLEKSQDVSV HITSNYLKQI LNAAYHVEVT FHSGSSVTRM
   541  LWEQIKQIIQ RITWVSPPAI TLEWKRKVAQ EAIESLSASK LAKSICSQFR TRLNSSHEAF
   601  AASLRQLEAG HSGRLEKTED LWLRVRKDHA PRLARLSLES CSLQDVLLHR KPKLGQELGR
   661  GQYGVVYLCD NWGGHFPCAL KSVVPPDEKH WNDLALEFHY MRSLPKHERL VDLHGSVIDY
   721  NYGGGSSIAV LLIMERLHRD LYTGLKAGLT LETRLQIALD VVEGIRFLHS QGLVHRDIKL
   781  KNVLLDKQNR AKITDLGFCK PEAMMSGSIV GTPIHMAPEL FTGKYDNSVD VYAFGILFWY
   841  ICSGSVKLPE AFERCASKDH LWNNVRRGAR PERLPVFDEE CWQLMEACWD GDPLKRPLLG
   901  IVQPMLQGIM NRLCKSNSEQ PNRGLDDST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DSTYK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.29

Highest tissue expression

18 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DSTYK.

Disease | AllUniProt

Conditions DSTYK is implicated in, by any mechanism.

• Congenital anomalies of the kidney and urinary tract 1 (CAKUT1) MIM:610805
• Spastic paraplegia 23, autosomal recessive (SPG23) MIM:270750

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 390 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Congenital anomalies of kidney and urinary tract 1
• Hereditary spastic paraplegia 23

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.37

gnomAD pLI

0.51

gnomAD missense Z

1.59

DepMap mean gene effect

-0.11

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular response to fibroblast growth factor stimulus
• negative regulation of apoptotic process
• positive regulation of ERK1 and ERK2 cascade
• positive regulation of fibroblast growth factor receptor signaling pathway
• positive regulation of kinase activity

Molecular functions

• ATP binding
• protein serine kinase activity
• protein serine/threonine kinase activity
• protein serine/threonine/tyrosine kinase activity
• protein tyrosine kinase activity

Cellular components

• anchoring junction
• apical plasma membrane
• basolateral plasma membrane
• cytoplasm

Protein domainsUniProt · Pfam · InterPro

• Protein kinase domain
• Serine/threonine-protein kinase, active site
• Protein kinase-like domain superfamily
• Protein kinase, ATP binding site
• Protein kinase domain
• Dual Ser/Thr and Tyr Protein Kinase

KeywordsUniProt

• ATP-binding
• Cell junction
• Cell membrane
• Coiled coil
• Cytoplasm
• Hereditary spastic paraplegia
• Kinase
• Membrane
• Neurodegeneration
• Nucleotide-binding
• Serine/threonine-protein kinase
• Transferase
• Tyrosine-protein kinase