DSCR8
Down syndrome critical region protein 8
Also known as: DSCR8_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for DSCR8 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
97 residues, UniProt reviewed canonical sequence.
>Q96T75|DSCR8
1 MKEPGPNFVT VRKGLHSFKM AFVKHLLLFL SPRLECSGSI TDHCSLHLPV QEILMSQPPE
61 QLGLQTNLGN QESSGMMKLF MPRPKVLAQY ESIQFMPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against DSCR8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.59
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.96
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.79
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads DSCR8 as an antibody target. Whether an autoantibody or antibody against DSCR8 could matter depends on whether native DSCR8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
DSCR8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label DSCR8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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