Seroatlas · Human Serome Atlas

DSCR4

Down syndrome critical region protein 4

Also known as: DSCR4_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P56555
Gene: DSCR4
Canonical length: 118 aa

OverviewNCBI Gene

No narrative summary is available for DSCR4 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

118 residues, UniProt reviewed canonical sequence.

>P56555|DSCR4
     1  MSLIILTRDD EPRIFTPDSD AASPALHSTS PLPDPASASP LHREEKILPK VCNIVSCLSF
    61  SLPASPTDSG LASPTIITRE GQQFWAKCLI WKYQLYLHGL HKKSDGRRDK QISASPST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DSCR4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.92
gnomAD pLI: 0
gnomAD missense Z: -0.16

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DSCR4 as an antibody target. Whether an autoantibody or antibody against DSCR4 could matter depends on whether native DSCR4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DSCR4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DSCR4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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