Seroatlas · Human Serome Atlas

DSCR10

Down syndrome critical region protein 10

Also known as: DSC10_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P59022
Gene: DSCR10
Canonical length: 87 aa

OverviewNCBI Gene

No narrative summary is available for DSCR10 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

87 residues, UniProt reviewed canonical sequence.

>P59022|DSCR10
     1  MQIVQGFPAD APLCALMWTC SFLLPGLQTE TPYPCTSLCL SSSQSAHPPL PVRVFSAESG
    61  YGIPFCAEPC SRVTVCHLQA VPVCMPV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DSCR10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DSCR10 as an antibody target. Whether an autoantibody or antibody against DSCR10 could matter depends on whether native DSCR10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DSCR10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DSCR10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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