Seroatlas · Human Serome Atlas

DSCAML1

Cell adhesion molecule DSCAML1

Also known as: DSCL1_HUMAN, KIAA1132

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TD84
Gene: DSCAML1
Ensembl: ENSG00000177103
Chromosome: 11
Canonical length: 2053 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the Ig superfamily of cell adhesion molecules and is involved in neuronal differentiation. The encoded membrane-bound protein localizes to the cell surface, where it forms aggregates that repel neuronal processes of the same cell type. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

2053 residues, UniProt reviewed canonical sequence.

>Q8TD84|DSCAML1
     1  MWLVTFLLLL DSLHKARPED VGTSLYFVND SLQQVTFSSS VGVVVPCPAA GSPSAALRWY
    61  LATGDDIYDV PHIRHVHANG TLQLYPFSPS AFNSFIHDND YFCTAENAAG KIRSPNIRVK
   121  AVFREPYTVR VEDQRSMRGN VAVFKCLIPS SVQEYVSVVS WEKDTVSIIP EHRFFITYHG
   181  GLYISDVQKE DALSTYRCIT KHKYSGETRQ SNGARLSVTD PAESIPTILD GFHSQEVWAG
   241  HTVELPCTAS GYPIPAIRWL KDGRPLPADS RWTKRITGLT ISDLRTEDSG TYICEVTNTF
   301  GSAEATGILM VIDPLHVTLT PKKLKTGIGS TVILSCALTG SPEFTIRWYR NTELVLPDEA
   361  ISIRGLSNET LLITSAQKSH SGAYQCFATR KAQTAQDFAI IALEDGTPRI VSSFSEKVVN
   421  PGEQFSLMCA AKGAPPPTVT WALDDEPIVR DGSHRTNQYT MSDGTTISHM NVTGPQIRDG
   481  GVYRCTARNL VGSAEYQARI NVRGPPSIRA MRNITAVAGR DTLINCRVIG YPYYSIKWYK
   541  DALLLPDNHR QVVFENGTLK LTDVQKGMDE GEYLCSVLIQ PQLSISQSVH VAVKVPPLIQ
   601  PFEFPPASIG QLLYIPCVVS SGDMPIRITW RKDGQVIISG SGVTIESKEF MSSLQISSVS
   661  LKHNGNYTCI ASNAAATVSR ERQLIVRVPP RFVVQPNNQD GIYGKAGVLN CSVDGYPPPK
   721  VMWKHAKGSG NPQQYHPVPL TGRIQILPNS SLLIRHVLEE DIGYYLCQAS NGVGTDISKS
   781  MFLTVKIPAM ITSHPNTTIA IKGHAKELNC TARGERPIII RWEKGDTVID PDRVMRYAIA
   841  TKDNGDEVVS TLKLKPADRG DSVFFSCHAI NSYGEDRGLI QLTVQEPPDP PELEIREVKA
   901  RSMNLRWTQR FDGNSIITGF DIEYKNKSDS WDFKQSTRNI SPTINQANIV DLHPASVYSI
   961  RMYSFNKIGR SEPSKELTIS TEEAAPDGPP MDVTLQPVTS QSIQVTWKAP KKELQNGVIR
  1021  GYQIGYRENS PGSNGQYSIV EMKATGDSEV YTLDNLKKFA QYGVVVQAFN RAGTGPSSSE
  1081  INATTLEDVP SQPPENVRAL SITSDVAVIS WSEPPRSTLN GVLKGYRVIF WSLYVDGEWG
  1141  EMQNITTTRE RVELRGMEKF TNYSVQVLAY TQAGDGVRSS VLYIQTKEDV PGPPAGIKAV
  1201  PSSASSVVVS WLPPTKPNGV IRKYTIFCSS PGSGQPAPSE YETSPEQLFY RIAHLNRGQQ
  1261  YLLWVAAVTS AGRGNSSEKV TIEPAGKAPA KIISFGGTVT TPWMKDVRLP CNSVGDPAPA
  1321  VKWTKDSEDS AIPVSMDGHR LIHTNGTLLL RAVKAEDSGY YTCTATNTGG FDTIIVNLLV
  1381  QVPPDQPRLT VSKTSASSIT LTWIPGDNGG SSIRGFVLQY SVDNSEEWKD VFISSSERSF
  1441  KLDSLKCGTW YKVKLAAKNS VGSGRISEII EAKTHGREPS FSKDQHLFTH INSTHARLNL
  1501  QGWNNGGCPI TAIVLEYRPK GTWAWQGLRA NSSGEVFLTE LREATWYELR MRACNSAGCG
  1561  NETAQFATLD YDGSTIPPIK SAQGEGDDVK KLFTIGCPVI LATLGVALLF IVRKKRKEKR
  1621  LKRLRDAKSL AEMLISKNNR SFDTPVKGPP QGPRLHIDIP RVQLLIEDKE GIKQLGDDKA
  1681  TIPVTDAEFS QAVNPQSFCT GVSLHHPTLI QSTGPLIDMS DIRPGTNPVS RKNVKSAHST
  1741  RNRYSSQWTL TKCQASTPAR TLTSDWRTVG SQHGVTVTES DSYSASLSQD TDKGRNSMVS
  1801  TESASSTYEE LARAYEHAKL EEQLQHAKFE ITECFISDSS SDQMTTGTNE NADSMTSMST
  1861  PSEPGICRFT ASPPKPQDAD RGKNVAVPIP HRANKSDYCN LPLYAKSEAF FRKADGREPC
  1921  PVVPPREASI RNLARTYHTQ ARHLTLDPAS KSLGLPHPGA PAAASTATLP QRTLAMPAPP
  1981  AGTAPPAPGP TPAEPPTAPS AAPPAPSTEP PRAGGPHTKM GGSRDSLLEM STSGVGRSQK
  2041  QGAGAYSKSY TLV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DSCAML1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

retina: 19 nTPM
spinal cord: 9.9 nTPM
hippocampal formation: 7.3 nTPM
cerebral cortex: 6.6 nTPM
basal ganglia: 5.9 nTPM
midbrain: 5.7 nTPM

Single-cell type

rod photoreceptor cells: 2,160 nCPM
retinal bipolar cells: 1,267 nCPM
oligodendrocytes: 885 nCPM
oligodendrocyte progenitor cells: 651 nCPM
renal collecting duct intercalated cells: 536 nCPM
loop of henle epithelial cells: 399 nCPM

Immune cell

T-reg: 0.6 nTPM
naive B-cell: 0.4 nTPM
memory B-cell: 0.3 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

white matter: 77 nTPM
cerebral cortex: 57 nTPM
thalamus: 55 nTPM
medulla oblongata: 53 nTPM
midbrain: 51 nTPM
pons: 50 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.17
gnomAD pLI: 1
gnomAD missense Z: 3.15
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DSCAML1 as an antibody target. Whether an autoantibody or antibody against DSCAML1 could matter depends on whether native DSCAML1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DSCAML1 is annotated at the cell surface, where native DSCAML1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label DSCAML1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...