Seroatlas · Human Serome Atlas

DRAXIN

Draxin

Also known as: C1orf187, DRAXI_HUMAN, FLJ34999, Neucrin

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NBI3
Gene: DRAXIN
Ensembl: ENSG00000162490
Chromosome: 1
Canonical length: 349 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted in brain

OverviewNCBI Gene

Enables molecular adaptor activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway and nervous system development. Predicted to act upstream of or within negative regulation of axon extension and negative regulation of hippocampal neuron apoptotic process. Predicted to be active in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

349 residues, UniProt reviewed canonical sequence.

>Q8NBI3|DRAXIN
     1  MAGPAIHTAP MLFLVLLLPL ELSLAGALAP GTPARNLPEN HIDLPGPALW TPQASHHRRR
    61  GPGKKEWGPG LPSQAQDGAV VTATRQASRL PEAEGLLPEQ SPAGLLQDKD LLLGLALPYP
   121  EKENRPPGWE RTRKRSREHK RRRDRLRLHQ GRALVRGPSS LMKKAELSEA QVLDAAMEES
   181  STSLAPTMFF LTTFEAAPAT EESLILPVTS LRPQQAQPRS DGEVMPTLDM ALFDWTDYED
   241  LKPDGWPSAK KKEKHRGKLS SDGNETSPAE GEPCDHHQDC LPGTCCDLRE HLCTPHNRGL
   301  NNKCFDDCMC VEGLRCYAKF HRNRRVTRRK GRCVEPETAN GDQGSFINV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DRAXIN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 1 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 1 nTPM
cerebellum: 1 nTPM
amygdala: 0.9 nTPM
cerebral cortex: 0.8 nTPM
salivary gland: 0.6 nTPM
bone marrow: 0.5 nTPM

Single-cell type

nk-cells: 16 nCPM
t-cells: 4.3 nCPM
undifferentiated spermatogonia: 3.5 nCPM
brain inhibitory neurons: 3.4 nCPM
late spermatids: 3.1 nCPM
neutrophil progenitors: 2.6 nCPM

Immune cell

basophil: 2.4 nTPM
neutrophil: 0.8 nTPM
gdT-cell: 0.5 nTPM
classical monocyte: 0.3 nTPM
memory CD8 T-cell: 0.3 nTPM
MAIT T-cell: 0.2 nTPM

Brain region

thalamus: 11 nTPM
medulla oblongata: 7.6 nTPM
amygdala: 5.3 nTPM
basal ganglia: 4.9 nTPM
cerebral cortex: 4.7 nTPM
white matter: 4.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.53
gnomAD pLI: 0
gnomAD missense Z: 1.32
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

Draxin
Draxin

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DRAXIN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

LRP6

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DRAXIN as an antibody target. Whether an autoantibody or antibody against DRAXIN could matter depends on whether native DRAXIN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DRAXIN is annotated as secreted, so native DRAXIN circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label DRAXIN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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