Seroatlas · Human Serome Atlas

DRAM2

DNA damage-regulated autophagy modulator protein 2

Also known as: DRAM2_HUMAN, MGC54289, PRO180, RP5-1180E21.1, TMEM77, WWFQ154

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6UX65
Gene
DRAM2
Ensembl
ENSG00000156171
Chromosome
1
Canonical length
266 aa
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location
Golgi apparatus,Vesicles

OverviewNCBI Gene

The protein encoded by this gene binds microtubule-associated protein 1 light chain 3 and is required for autophagy. Defects in this gene are a cause of retinal dystrophy. In addition, two microRNAs (microRNA 125b-1 and microRNA 144) can bind to the mRNA of this gene and produce the disease state. [provided by RefSeq, Mar 2017]

Canonical amino-acid sequenceUniProt

266 residues, UniProt reviewed canonical sequence.

>Q6UX65|DRAM2
     1  MWWFQQGLSF LPSALVIWTS AAFIFSYITA VTLHHIDPAL PYISDTGTVA PEKCLFGAML
    61  NIAAVLCIAT IYVRYKQVHA LSPEENVIIK LNKAGLVLGI LSCLGLSIVA NFQKTTLFAA
   121  HVSGAVLTFG MGSLYMFVQT ILSYQMQPKI HGKQVFWIRL LLVIWCGVSA LSMLTCSSVL
   181  HSGNFGTDLE QKLHWNPEDK GYVLHMITTA AEWSMSFSFF GFFLTYIRDF QKISLRVEAN
   241  LHGLTLYDTA PCPINNERTR LLSRDI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DRAM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
52 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 52 nTPM
  • tonsil: 47 nTPM
  • spleen: 43 nTPM
  • placenta: 39 nTPM
  • adipose tissue: 36 nTPM
  • choroid plexus: 35 nTPM

Single-cell type

  • kupffer cells: 236 nCPM
  • hofbauer cells: 229 nCPM
  • b-cells: 197 nCPM
  • parietal cells: 150 nCPM
  • extravillous trophoblasts: 142 nCPM
  • cytotrophoblasts: 125 nCPM

Immune cell

  • memory B-cell: 66 nTPM
  • intermediate monocyte: 61 nTPM
  • naive B-cell: 54 nTPM
  • non-classical monocyte: 50 nTPM
  • classical monocyte: 47 nTPM
  • myeloid DC: 45 nTPM

Brain region

  • choroid plexus: 28 nTPM
  • white matter: 18 nTPM
  • cerebellum: 17 nTPM
  • medulla oblongata: 15 nTPM
  • spinal cord: 13 nTPM
  • hypothalamus: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DRAM2.

Disease | AllUniProt

Conditions DRAM2 is implicated in, by any mechanism.

Disease | GeneticClinVar

29 pathogenic / likely-pathogenic of 220 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.08
gnomAD pLI
0
gnomAD missense Z
0.45
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DRAM2 as an antibody target. Whether an autoantibody or antibody against DRAM2 could matter depends on whether native DRAM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DRAM2 is annotated at the cell surface, where native DRAM2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label DRAM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DRAM2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...