Seroatlas · Human Serome Atlas

DRAM1

DNA damage-regulated autophagy modulator protein 1

Also known as: DRAM, DRAM1_HUMAN, FLJ11259

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N682
Gene: DRAM1
Ensembl: ENSG00000136048
Chromosome: 12
Canonical length: 238 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

238 residues, UniProt reviewed canonical sequence.

>Q8N682|DRAM1
     1  MLCFLRGMAF VPFLLVTWSS AAFIISYVVA VLSGHVNPFL PYISDTGTTP PESGIFGFMI
    61  NFSAFLGAAT MYTRYKIVQK QNQTCYFSTP VFNLVSLVLG LVGCFGMGIV ANFQELAVPV
   121  VHDGGALLAF VCGVVYTLLQ SIISYKSCPQ WNSLSTCHIR MVISAVSCAA VIPMIVCASL
   181  ISITKLEWNP REKDYVYHVV SAICEWTVAF GFIFYFLTFI QDFQSVTLRI STEINGDI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DRAM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 89 nTPM

Expression across tissuesHPA

Tissue

lung: 89 nTPM
urinary bladder: 35 nTPM
bone marrow: 34 nTPM
kidney: 22 nTPM
placenta: 19 nTPM
appendix: 18 nTPM

Single-cell type

alveolar cells type 2: 465 nCPM
neutrophils: 424 nCPM
transitional alveolar cells: 269 nCPM
early spermatids: 269 nCPM
monocytes: 247 nCPM
neutrophil progenitors: 191 nCPM

Immune cell

basophil: 10 nTPM
intermediate monocyte: 10 nTPM
classical monocyte: 9 nTPM
neutrophil: 8.6 nTPM
eosinophil: 6 nTPM
non-classical monocyte: 5.9 nTPM

Brain region

choroid plexus: 27 nTPM
cerebellum: 25 nTPM
white matter: 22 nTPM
thalamus: 21 nTPM
hypothalamus: 21 nTPM
cerebral cortex: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.67
gnomAD pLI: 0.23
gnomAD missense Z: 1.32
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DRAM1 as an antibody target. Whether an autoantibody or antibody against DRAM1 could matter depends on whether native DRAM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DRAM1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DRAM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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