Seroatlas · Human Serome Atlas

DPY19L3

Protein C-mannosyl-transferase DPY19L3

Also known as: D19L3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZPD9
Gene: DPY19L3
Ensembl: ENSG00000178904
Chromosome: 19
Canonical length: 716 aa
Protein class: Predicted membrane proteins
Subcellular location: Microtubules

OverviewNCBI Gene

Enables mannosyltransferase activity. Predicted to be involved in protein glycosylation. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

716 residues, UniProt reviewed canonical sequence.

>Q6ZPD9|DPY19L3
     1  MMSIRQRREI RATEVSEDFP AQEENVKLEN KLPSGCTSRR LWKILSLTIG GTIALCIGLL
    61  TSVYLATLHE NDLWFSNIKE VEREISFRTE CGLYYSYYKQ MLQAPTLVQG FHGLIYDNKT
   121  ESMKTINLLQ RMNIYQEVFL SILYRVLPIQ KYLEPVYFYI YTLFGLQAIY VTALYITSWL
   181  LSGTWLSGLL AAFWYVTNRI DTTRVEFTIP LRENWALPFF AIQIAAITYF LRPNLQPLSE
   241  RLTLLAIFIS TFLFSLTWQF NQFMMLMQAL VLFTLDSLDM LPAVKATWLY GIQITSLLLV
   301  CILQFFNSMI LGSLLISFNL SVFIARKLQK NLKTGSFLNR LGKLLLHLFM VLCLTLFLNN
   361  IIKKILNLKS DEHIFKFLKA KFGLGATRDF DANLYLCEEA FGLLPFNTFG RLSDTLLFYA
   421  YIFVLSITVI VAFVVAFHNL SDSTNQQSVG KMEKGTVDLK PETAYNLIHT ILFGFLALST
   481  MRMKYLWTSH MCVFASFGLC SPEIWELLLK SVHLYNPKRI CIMRYSVPIL ILLYLCYKFW
   541  PGMMDELSEL REFYDPDTVE LMNWINSNTP RKAVFAGSMQ LLAGVKLCTG RTLTNHPHYE
   601  DSSLRERTRA VYQIYAKRAP EEVHALLRSF GTDYVILEDS ICYERRHRRG CRLRDLLDIA
   661  NGHMMDGPGE NDPDLKPADH PRFCEEIKRN LPPYVAYFTR VFQNKTFHVY KLSRNK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DPY19L3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 11
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 13 nTPM
amygdala: 12 nTPM
cerebral cortex: 11 nTPM
ovary: 11 nTPM
hippocampal formation: 10 nTPM
prostate: 10 nTPM

Single-cell type

retinal horizontal cells: 297 nCPM
bergmann glia: 251 nCPM
podocytes: 203 nCPM
somatotrophs: 162 nCPM
neutrophil progenitors: 151 nCPM
prostatic glandular cells: 146 nCPM

Immune cell

neutrophil: 5.8 nTPM
basophil: 5.3 nTPM
eosinophil: 5.2 nTPM
non-classical monocyte: 1.8 nTPM
classical monocyte: 1.6 nTPM
naive B-cell: 1.6 nTPM

Brain region

hippocampal formation: 36 nTPM
choroid plexus: 35 nTPM
hypothalamus: 34 nTPM
basal ganglia: 32 nTPM
cerebellum: 32 nTPM
midbrain: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.66
gnomAD pLI: 0
gnomAD missense Z: 1.67
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

mannosyltransferase activity

Cellular components

endoplasmic reticulum membrane

Protein domainsUniProt · Pfam · InterPro

Dpy-19/Dpy-19-like
Q-cell neuroblast polarisation
C-mannosyltransferase Dpy-19-like protein 3

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DPY19L3 as an antibody target. Whether an autoantibody or antibody against DPY19L3 could matter depends on whether native DPY19L3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DPY19L3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DPY19L3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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