Seroatlas · Human Serome Atlas

DPY19L2P2

Putative C-mannosyltransferase DPY19L2P2

Also known as: D19P2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZN68
Gene: DPY19L2P2
Canonical length: 376 aa

OverviewNCBI Gene

No narrative summary is available for DPY19L2P2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

376 residues, UniProt reviewed canonical sequence.

>Q6ZN68|DPY19L2P2
     1  MADSRRVIIA SWYRTFMGIV NLFGLETKTC WNVTRIEPLN EVQSCEGLRD PACFYVGVIF
    61  ILNGLMMGLF FIYGTYLSGT ELGGLITVLC FFFNHGEATC VMWTPPLRES FSYPFLVLQM
   121  YVLTLILRTS SNDRRPFIAL CLSNVAFMLP WQFAQFILFT QIASLFPMYV VGYIEPSKFQ
   181  KIIYMNMISV TLSFILMFGN SMYLSSYYSS SLLMTWAIIL KRNEIQKLGV SKLNCWLIQG
   241  SAWWCGTIIL KFLTSKILGV SDHICLSDLI AAGILRYTDF DTLKYTCSPE FDFMEKATLL
   301  IYTKTLLLPV VMVITCFIFK KTVGDISRVL ATNVYLRCCL CRCHAYNGKC QAVYTSSHCE
   361  SSTLRRCRLE AWLQHA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DPY19L2P2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.34

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DPY19L2P2 as an antibody target. Whether an autoantibody or antibody against DPY19L2P2 could matter depends on whether native DPY19L2P2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DPY19L2P2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DPY19L2P2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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