Seroatlas · Human Serome Atlas

DPY19L2P1

Putative C-mannosyltransferase DPY19L2P1

Also known as: D19P1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6NXN4
Gene: DPY19L2P1
Canonical length: 242 aa

OverviewNCBI Gene

No narrative summary is available for DPY19L2P1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

242 residues, UniProt reviewed canonical sequence.

>Q6NXN4|DPY19L2P1
     1  MKKQGVNPKP LQSSRPSPSK RPYGASPARE LEVEKSALGG GKLPGGARRS SPGRIPNLKK
    61  RKGLELKVVA KTLLDPFQFV RNSLAQLREE VHELQARWFP SRTTLSIAIF VAILHWLHLV
   121  TLFENDRHFS HLSSLEWEMT FRTKMGLYYS YFKTIIEAPS FLEGLWMIMN DRLTEYPLVI
   181  NTVKRFHLYP EVIIAAWYRT FIGIMNLFGL ETKTCWNVTR IEPLNEFKAV KDWEILLAFM
   241  LV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DPY19L2P1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.49

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

glycosyltransferase activity

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DPY19L2P1 as an antibody target. Whether an autoantibody or antibody against DPY19L2P1 could matter depends on whether native DPY19L2P1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DPY19L2P1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DPY19L2P1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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