Seroatlas · Human Serome Atlas

DPY19L1

Protein C-mannosyl-transferase DPY19L1

Also known as: D19L1_HUMAN, KIAA0877

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2PZI1
Gene: DPY19L1
Ensembl: ENSG00000173852
Chromosome: 7
Canonical length: 675 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to enable mannosyltransferase activity. Predicted to be involved in protein glycosylation. Located in membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

675 residues, UniProt reviewed canonical sequence.

>Q2PZI1|DPY19L1
     1  MEGRPPPEGR PPPRPRTGRA PRGRRRAVFA AVLHWSHITH LFENDRHFSH LSTLEREMAF
    61  RTEMGLYYSY FKTIVEAPSF LNGVWMIMND KLTEYPLVIN TLKRFNLYPE VILASWYRIY
   121  TKIMDLIGIQ TKICWTVTRG EGLSPIESCE GLGDPACFYV AVIFILNGLM MALFFIYGTY
   181  LSGSRLGGLV TVLCFFFNHG ECTRVMWTPP LRESFSYPFL VLQMLLVTHI LRATKLYRGS
   241  LIALCISNVF FMLPWQFAQF VLLTQIASLF AVYVVGYIDI CKLRKIIYIH MISLALCFVL
   301  MFGNSMLLTS YYASSLVIIW GILAMKPHFL KINVSELSLW VIQGCFWLFG TVILKYLTSK
   361  IFGIADDAHI GNLLTSKFFS YKDFDTLLYT CAAEFDFMEK ETPLRYTKTL LLPVVLVVFV
   421  AIVRKIISDM WGVLAKQQTH VRKHQFDHGE LVYHALQLLA YTALGILIMR LKLFLTPHMC
   481  VMASLICSRQ LFGWLFCKVH PGAIVFAILA AMSIQGSANL QTQWNIVGEF SNLPQEELIE
   541  WIKYSTKPDA VFAGAMPTMA SVKLSALRPI VNHPHYEDAG LRARTKIVYS MYSRKAAEEV
   601  KRELIKLKVN YYILEESWCV RRSKPGCSMP EIWDVEDPAN AGKTPLCNLL VKDSKPHFTT
   661  VFQNSVYKVL EVVKE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DPY19L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 11
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 27 nTPM
testis: 26 nTPM
retina: 23 nTPM
cerebral cortex: 20 nTPM
placenta: 20 nTPM
liver: 18 nTPM

Single-cell type

early spermatids: 287 nCPM
platelets: 223 nCPM
alveolar cells type 1: 208 nCPM
sertoli cells: 160 nCPM
alveolar cells type 2: 133 nCPM
ependymal cells: 128 nCPM

Immune cell

gdT-cell: 1.2 nTPM
MAIT T-cell: 1.2 nTPM
memory CD8 T-cell: 1 nTPM
intermediate monocyte: 0.6 nTPM
naive B-cell: 0.6 nTPM
NK-cell: 0.6 nTPM

Brain region

white matter: 65 nTPM
spinal cord: 56 nTPM
medulla oblongata: 52 nTPM
hypothalamus: 50 nTPM
thalamus: 50 nTPM
midbrain: 49 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.56
gnomAD pLI: 0
gnomAD missense Z: 1.38
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

mannosyltransferase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Dpy-19/Dpy-19-like
Q-cell neuroblast polarisation
C-mannosyltransferase Dpy-19-like protein 1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DPY19L1 as an antibody target. Whether an autoantibody or antibody against DPY19L1 could matter depends on whether native DPY19L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DPY19L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DPY19L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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