DPRX

Protein identityUniProt · HPA

UniProt accession

A6NFQ7

Gene

DPRX

Ensembl

ENSG00000204595

Chromosome

19

Canonical length

191 aa

Protein class

Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the DPRX homeobox gene family. Evidence of mRNA expression has not yet been found for this gene. Multiple, related processed pseudogenes have been found which are thought to reflect expression of this gene in the germ line or embryonic cells. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

191 residues, UniProt reviewed canonical sequence.

>A6NFQ7|DPRX
     1  MPGSEDLRKG KDQMHSHRKR TMFTKKQLED LNILFNENPY PNPSLQKEMA SKIDIHPTVL
    61  QVWFKNHRAK LKKAKCKHIH QKQETPQPPI PEGGVSTSVG LRNADTLPRL PNAAHPIGLV
   121  YTGHRVPSFQ LILYPNLKVP ANDFIGHRIV HFGCCRDPNI YCLYPILESQ VCAPSFHSGS
   181  PACSSNQSRE R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DPRX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.54

Highest tissue expression

1 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DPRX.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 36 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Short stature

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.95

gnomAD pLI

0

gnomAD missense Z

1

DepMap mean gene effect

-0.03

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• regulation of transcription by RNA polymerase II

Molecular functions

• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• sequence-specific double-stranded DNA binding

Cellular components

• chromatin
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Homeodomain
• Homedomain-like superfamily
• Homeobox, conserved site
• Homeodomain

KeywordsUniProt

• DNA-binding
• Homeobox
• Nucleus
• Repressor
• Transcription
• Transcription regulation