DPPA5
Developmental pluripotency-associated 5 protein
Also known as: DPPA5_HUMAN, Esg1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A6NC42
- Gene
- DPPA5
- Ensembl
- ENSG00000203909
- Chromosome
- 6
- Canonical length
- 116 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Cell Junctions
OverviewNCBI Gene
This gene encodes a protein that may function in the control of cell pluripotency and early embryogenesis. Expression of this gene is a specific marker for pluripotent stem cells. Pseudogenes of this gene are located on the short arm of chromosome 10 and the long arm of chromosomes 14 and 19. [provided by RefSeq, Dec 2010]
Canonical amino-acid sequenceUniProt
116 residues, UniProt reviewed canonical sequence.
>A6NC42|DPPA5
1 MGTLPARRHI PPWVKVPEDL KDPEVFQVQT RLLKAIFGPD GSRIPYIEQV SKAMLELKAL
61 ESSDLTEVVV YGSYLYKLRT KWMLQSMAEW HRQRQERGML KLAEAMNALE LGPWMKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against DPPA5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.37
- Highest tissue expression
- 2 nTPM
Expression across tissuesHPA
Tissue
- testis: 2 nTPM
- ovary: 0.6 nTPM
- lung: 0.5 nTPM
- duodenum: 0.1 nTPM
- spleen: 0.1 nTPM
- thyroid gland: 0.1 nTPM
Single-cell type
- oocytes: 207 nCPM
- undifferentiated spermatogonia: 3 nCPM
- early primary spermatocytes: 2.1 nCPM
- ovarian stromal cells: 0.6 nCPM
- late primary spermatocytes: 0.5 nCPM
- t-cells: 0.4 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 0.4 nTPM
- hippocampal formation: 0.4 nTPM
- cerebellum: 0.3 nTPM
- pons: 0.3 nTPM
- amygdala: 0.2 nTPM
- basal ganglia: 0.2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.58
- gnomAD pLI
- 0
- gnomAD missense Z
- 1.22
- DepMap mean gene effect
- -0.15
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads DPPA5 as an antibody target. Whether an autoantibody or antibody against DPPA5 could matter depends on whether native DPPA5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
DPPA5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label DPPA5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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