DPPA3
Developmental pluripotency-associated protein 3
Also known as: DPPA3_HUMAN, Pgc7, Stella
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6W0C5
- Gene
- DPPA3
- Ensembl
- ENSG00000187569
- Chromosome
- 12
- Canonical length
- 159 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
This gene encodes a protein that in mice may function as a maternal factor during the preimplantation stage of development. In mice, this gene may play a role in transcriptional repression, cell division, and maintenance of cell pluripotentiality. In humans, related intronless loci are located on chromosomes 14 and X. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
159 residues, UniProt reviewed canonical sequence.
>Q6W0C5|DPPA3
1 MDPSQFNPTY IPGSPQMLTE ENSRDDSGAS QISSETLIKN LSNLTINASS ESVSPLSEAL
61 LRRESVGAAV LREIEDEWLY SRRGVRTLLS VQREKMARLR YMLLGGVRTH ERRPTNKEPK
121 GVKKESRPFK CPCSFCVSNG WDPSENARIG NQDTKPLQPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against DPPA3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.6
- Highest tissue expression
- 3 nTPM
Expression across tissuesHPA
Tissue
- ovary: 3 nTPM
- fallopian tube: 1 nTPM
- testis: 1 nTPM
- lung: 0.4 nTPM
- duodenum: 0.2 nTPM
- bone marrow: 0.1 nTPM
Single-cell type
- oocytes: 903 nCPM
- migrating cytotrophoblasts: 2.6 nCPM
- undifferentiated spermatogonia: 2.4 nCPM
- early primary spermatocytes: 1.5 nCPM
- cytotrophoblasts: 1.1 nCPM
- syncytiotrophoblasts: 0.8 nCPM
Immune cell
- eosinophil: 0.5 nTPM
- plasmacytoid DC: 0.5 nTPM
- basophil: 0.1 nTPM
- classical monocyte: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- midbrain: 1.1 nTPM
- cerebellum: 1 nTPM
- medulla oblongata: 0.9 nTPM
- cerebral cortex: 0.8 nTPM
- pons: 0.8 nTPM
- white matter: 0.8 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.89
- gnomAD pLI
- 0.22
- gnomAD missense Z
- -0.25
- DepMap mean gene effect
- -0.22
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads DPPA3 as an antibody target. Whether an autoantibody or antibody against DPPA3 could matter depends on whether native DPPA3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
DPPA3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label DPPA3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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