Seroatlas · Human Serome Atlas

DPP7

Dipeptidyl peptidase 2

Also known as: DPP2, DPP2_HUMAN, DPPII

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UHL4
Gene
DPP7
Ensembl
ENSG00000176978
Chromosome
9
Canonical length
492 aa
Protein class
Enzymes, Plasma proteins, Predicted secreted proteins
Subcellular location
Golgi apparatus,Vesicles
Secretome location
Secreted - unknown location
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. The resting lymphocytes are maintained through suppression of apoptosis, a state which is disrupted by inhibition of this novel serine protease. The enzyme has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

492 residues, UniProt reviewed canonical sequence.

>Q9UHL4|DPP7
     1  MGSAPWAPVL LLALGLRGLQ AGARRAPDPG FQERFFQQRL DHFNFERFGN KTFPQRFLVS
    61  DRFWVRGEGP IFFYTGNEGD VWAFANNSAF VAELAAERGA LLVFAEHRYY GKSLPFGAQS
   121  TQRGHTELLT VEQALADFAE LLRALRRDLG AQDAPAIAFG GSYGGMLSAY LRMKYPHLVA
   181  GALAASAPVL AVAGLGDSNQ FFRDVTADFE GQSPKCTQGV REAFRQIKDL FLQGAYDTVR
   241  WEFGTCQPLS DEKDLTQLFM FARNAFTVLA MMDYPYPTDF LGPLPANPVK VGCDRLLSEA
   301  QRITGLRALA GLVYNASGSE HCYDIYRLYH SCADPTGCGT GPDARAWDYQ ACTEINLTFA
   361  SNNVTDMFPD LPFTDELRQR YCLDTWGVWP RPDWLLTSFW GGDLRAASNI IFSNGNLDPW
   421  AGGGIRRNLS ASVIAVTIQG GAHHLDLRAS HPEDPASVVE ARKLEATIIG EWVKAARREQ
   481  QPALRGGPRL SL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DPP7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
104 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 104 nTPM
  • pituitary gland: 101 nTPM
  • choroid plexus: 93 nTPM
  • adrenal gland: 90 nTPM
  • salivary gland: 82 nTPM
  • thyroid gland: 77 nTPM

Single-cell type

  • late spermatids: 1,745 nCPM
  • hofbauer cells: 426 nCPM
  • late primary spermatocytes: 295 nCPM
  • early spermatids: 289 nCPM
  • pancreatic islet cells: 255 nCPM
  • kupffer cells: 204 nCPM

Immune cell

  • plasmacytoid DC: 231 nTPM
  • total PBMC: 171 nTPM
  • classical monocyte: 168 nTPM
  • myeloid DC: 162 nTPM
  • intermediate monocyte: 150 nTPM
  • T-reg: 146 nTPM

Brain region

  • choroid plexus: 132 nTPM
  • hypothalamus: 66 nTPM
  • medulla oblongata: 60 nTPM
  • thalamus: 59 nTPM
  • white matter: 58 nTPM
  • midbrain: 58 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.61
gnomAD pLI
0
gnomAD missense Z
-1.16
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DPP7 as an antibody target. Whether an autoantibody or antibody against DPP7 could matter depends on whether native DPP7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DPP7 is annotated as secreted, so native DPP7 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label DPP7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DPP7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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