Seroatlas · Human Serome Atlas

DPP10

Inactive dipeptidyl peptidase 10

Also known as: DPL2, DPP10_HUMAN, DPPY, DPRP3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N608
Gene
DPP10
Ensembl
ENSG00000175497
Chromosome
2
Canonical length
796 aa
Protein class
Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

796 residues, UniProt reviewed canonical sequence.

>Q8N608|DPP10
     1  MNQTASVSHH IKCQPSKTIK ELGSNSPPQR NWKGIAIALL VILVVCSLIT MSVILLTPDE
    61  LTNSSETRLS LEDLFRKDFV LHDPEARWIN DTDVVYKSEN GHVIKLNIET NATTLLLENT
   121  TFVTFKASRH SVSPDLKYVL LAYDVKQIFH YSYTASYVIY NIHTREVWEL NPPEVEDSVL
   181  QYAAWGVQGQ QLIYIFENNI YYQPDIKSSS LRLTSSGKEE IIFNGIADWL YEEELLHSHI
   241  AHWWSPDGER LAFLMINDSL VPTMVIPRFT GALYPKGKQY PYPKAGQVNP TIKLYVVNLY
   301  GPTHTLELMP PDSFKSREYY ITMVKWVSNT KTVVRWLNRA QNISILTVCE TTTGACSKKY
   361  EMTSDTWLSQ QNEEPVFSRD GSKFFMTVPV KQGGRGEFHH VAMFLIQSKS EQITVRHLTS
   421  GNWEVIKILA YDETTQKIYF LSTESSPRGR QLYSASTEGL LNRQCISCNF MKEQCTYFDA
   481  SFSPMNQHFL LFCEGPRVPV VSLHSTDNPA KYFILESNSM LKEAILKKKI GKPEIKILHI
   541  DDYELPLQLS LPKDFMDRNQ YALLLIMDEE PGGQLVTDKF HIDWDSVLID MDNVIVARFD
   601  GRGSGFQGLK ILQEIHRRLG SVEVKDQITA VKFLLKLPYI DSKRLSIFGK GYGGYIASMI
   661  LKSDEKLFKC GSVVAPITDL KLYASAFSER YLGMPSKEES TYQAASVLHN VHGLKEENIL
   721  IIHGTADTKV HFQHSAELIK HLIKAGVNYT MQVYPDEGHN VSEKSKYHLY STILKFFSDC
   781  LKEEISVLPQ EPEEDE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DPP10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 20 nTPM
  • pancreas: 16 nTPM
  • amygdala: 12 nTPM
  • adrenal gland: 10 nTPM
  • basal ganglia: 9.7 nTPM
  • hypothalamus: 8.8 nTPM

Single-cell type

  • ependymal cells: 9,176 nCPM
  • astrocytes: 7,509 nCPM
  • brain inhibitory neurons: 1,579 nCPM
  • brain excitatory neurons: 1,557 nCPM
  • other brain neurons: 1,266 nCPM
  • oligodendrocyte progenitor cells: 1,148 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 79 nTPM
  • basal ganglia: 68 nTPM
  • white matter: 63 nTPM
  • thalamus: 49 nTPM
  • amygdala: 49 nTPM
  • hippocampal formation: 47 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DPP10.

Disease | AllUniProt

Conditions DPP10 is implicated in, by any mechanism.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 140 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.18
gnomAD pLI
1
gnomAD missense Z
1.22
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DPP10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DPP10 as an antibody target. Whether an autoantibody or antibody against DPP10 could matter depends on whether native DPP10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DPP10 is annotated at the cell surface, where native DPP10 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label DPP10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DPP10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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