Seroatlas · Human Serome Atlas

DPEP2NB

DPEP2 neighbor protein

Also known as: DP2NB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A0U1RQF7
Gene
DPEP2NB
Ensembl
ENSG00000263201
Chromosome
16
Canonical length
123 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for DPEP2NB in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

123 residues, UniProt reviewed canonical sequence.

>A0A0U1RQF7|DPEP2NB
     1  MTDRILYIVS NMSSVPWEGS AAAAVPATSP PTPGHYHVLY RGCGETQVGW HGETYCLVGG
    61  YRVHGDAPLA TPTKAEAEKP APRRAPKRRQ ATIESDKDLG CSSPKIRRLE HRGRRLTPQK
   121  LAG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DPEP2NB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
3.9 nTPM

Expression across tissuesHPA

Tissue

  • testis: 3.9 nTPM
  • placenta: 0.8 nTPM
  • bone marrow: 0.3 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM

Single-cell type

  • syncytiotrophoblasts: 84 nCPM
  • early spermatids: 19 nCPM
  • late primary spermatocytes: 13 nCPM
  • late spermatids: 3.8 nCPM
  • migrating cytotrophoblasts: 1.2 nCPM
  • sertoli cells: 1.1 nCPM

Immune cell

  • eosinophil: 1 nTPM
  • neutrophil: 0.6 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • basal ganglia: 0.2 nTPM
  • cerebellum: 0.2 nTPM
  • hypothalamus: 0.2 nTPM
  • medulla oblongata: 0.2 nTPM
  • midbrain: 0.2 nTPM
  • pons: 0.2 nTPM

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DPEP2NB as an antibody target. Whether an autoantibody or antibody against DPEP2NB could matter depends on whether native DPEP2NB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DPEP2NB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DPEP2NB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DPEP2NB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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