Seroatlas · Human Serome Atlas

DORIP1

Dopamine receptor-interacting protein 1

Also known as: C14orf28, DRIP-1, DRIP1, DRIP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q4W4Y0
Gene: DORIP1
Ensembl: ENSG00000179476
Chromosome: 14
Canonical length: 310 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to act upstream of or within with a positive effect on NMDA selective glutamate receptor signaling pathway and cAMP-mediated signaling. Predicted to act upstream of or within several processes, including G protein-coupled dopamine receptor signaling pathway; memory; and neurogenesis. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

310 residues, UniProt reviewed canonical sequence.

>Q4W4Y0|DORIP1
     1  MKTLFEEIKA SIKNNYNQDR SFCRPVLPWG GVFTIKAGRK AVSCTPLYVE IRLKNTCTID
    61  GFLMLLYVIL NENENFPREL SLHFGREFVD CFLYLMDTYS FTTVKLLWIW DKMEKQQYKS
   121  EVHKASLIID LFGNEHDNFT KNLENLMSTI QESYCSNWRC PTRVQEDQQR TININPPQEI
   181  PHGNLIRLAV NELFCSKIEL CEEHGCGGLR EFSQRIFCHG APPFVVLNMQ HWKSEDLAYV
   241  PYYLDLSDHK YLLEGATLFN KEEHHYSAAF QIGGHWMHYD GLRNVNLILL NKPPEFLLLS
   301  SLVYIRATEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DORIP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 8 nTPM

Expression across tissuesHPA

Tissue

testis: 8 nTPM
ovary: 5.6 nTPM
endometrium: 5.2 nTPM
adipose tissue: 5 nTPM
blood vessel: 4.9 nTPM
colon: 4.8 nTPM

Single-cell type

early spermatids: 179 nCPM
late spermatids: 176 nCPM
late primary spermatocytes: 86 nCPM
smooth muscle cells: 25 nCPM
parietal cells: 23 nCPM
cardiomyocytes: 21 nCPM

Immune cell

naive CD4 T-cell: 5.5 nTPM
memory B-cell: 4.8 nTPM
eosinophil: 4.6 nTPM
memory CD8 T-cell: 3.3 nTPM
naive CD8 T-cell: 3.2 nTPM
naive B-cell: 3.1 nTPM

Brain region

white matter: 4 nTPM
medulla oblongata: 3.5 nTPM
basal ganglia: 3.3 nTPM
pons: 3.1 nTPM
thalamus: 3.1 nTPM
midbrain: 3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.51
gnomAD pLI: 0
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Protein domainsUniProt · Pfam · InterPro

Dopamine receptor-interacting protein 1

InteractionsUniProt · HPA

Protein binding partners of DORIP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

DRD1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DORIP1 as an antibody target. Whether an autoantibody or antibody against DORIP1 could matter depends on whether native DORIP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DORIP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DORIP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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