Seroatlas · Human Serome Atlas

DOP1A

Protein DOP1A

Also known as: dJ202D23.2, DOP1A_HUMAN, DOPEY1, KIAA1117

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5JWR5
Gene
DOP1A
Ensembl
ENSG00000083097
Chromosome
6
Canonical length
2465 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Vesicles

OverviewNCBI Gene

Predicted to be involved in Golgi to endosome transport and endoplasmic reticulum organization. Predicted to be located in Golgi membrane. Predicted to be active in endosome and trans-Golgi network. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

2465 residues, UniProt reviewed canonical sequence.

>Q5JWR5|DOP1A
     1  MNTEELELLS DSKYRNYVAA IDKALKNFEY SSEWADLISA LGKLNKVLQN NAKYQVVPKK
    61  LTIGKRLAQC LHPALPGGVH RKALETYEII FKIIGPKRLA KDLFLYSSGL FPLLANAAMS
   121  VKPTLLSLYE IYYLPLGKTL KPGLQGLLTG ILPGLEEGSE YYERTNMLLE KVAAAVDQSA
   181  FYSALWGSLL TSPAVRLPGI TYVLAHLNRK LSMEDQLYII GSDIELMVEA VSTSVQDSSV
   241  LVQRSTLDLI LFCFPFHMSQ ATRPDMIRIL SAALHVVLRR DMSLNRRLYA WLLGFDNNGA
   301  IIGPRSTRHS NPEEHATYYF TTFSKELLVQ AMVGILQVNG FGEENTLMQD LKPFRILISL
   361  LDKPELGPVI LEDVLIEVFR TLYSQCKAEL DLQTEPPFSK DHAQLSSKLR ENKKTAELIK
   421  TANLLFNSFE PYYMWDYVAR WFEECCRRTL HVRLQIGPGD SNDSSELQLT NFCLLVDFLL
   481  DIVSLPTRSM RVLCQETYIE IQTEHLPQLL LRMISALTSH LQTLHLSELT DSLRLCSKIL
   541  SKVQPPLLSA STGGVLQFPS GQNNSVKEWE DKKVSSVSHE NPTEVFEDGE NPPSSRSSES
   601  GFTEFIQYQA DRTDDIDREL SEGQGAAAIP IGSTSSETET ASTVGSEETI IQTPSVVTQG
   661  TATRSRKTAQ KTAMQCCLEY VQQFLTRLIN LYIIQNNSFS QSLATEHQGD LGREQGETSK
   721  WDRNSQGDVK EKNISKQKTS KEYLSAFLAA CQLFLECSSF PVYIAEGNHT SELRSEKLET
   781  DCEHVQPPQW LQTLMNACSQ ASDFSVQSVA ISLVMDLVGL TQSVAMVTGE NINSVEPAQP
   841  LSPNQGRVAV VIRPPLTQGN LRYIAEKTEF FKHVALTLWD QLGDGTPQHH QKSVELFYQL
   901  HNLVPSSSIC EDVISQQLTH KDKKIRMEAH AKFAVLWHLT RDLHINKSSS FVRSFDRSLF
   961  IMLDSLNSLD GSTSSVGQAW LNQVLQRHDI ARVLEPLLLL LLHPKTQRVS VQRVQAERYW
  1021  NKSPCYPGEE SDKHFMQNFA CSNVSQVQLI TSKGNGEKPL TMDEIENFSL TVNPLSDRLS
  1081  LLSTSSETIP MVVSDFDLPD QQIEILQSSD SGCSQSSAGD NLSYEVDPET VNAQEDSQMP
  1141  KESSPDDDVQ QVVFDLICKV VSGLEVESAS VTSQLEIEAM PPKCSDIDPD EETIKIEDDS
  1201  IQQSQNALLS NESSQFLSVS AEGGHECVAN GISRNSSSPC ISGTTHTLHD SSVASIETKS
  1261  RQRSHSSIQF SFKEKLSEKV SEKETIVKES GKQPGAKPKV KLARKKDDDK KKSSNEKLKQ
  1321  TSVFFSDGLD LENWYSCGEG DISEIESDMG SPGSRKSPNF NIHPLYQHVL LYLQLYDSSR
  1381  TLYAFSAIKA ILKTNPIAFV NAISTTSVNN AYTPQLSLLQ NLLARHRISV MGKDFYSHIP
  1441  VDSNHNFRSS MYIEILISLC LYYMRSHYPT HVKVTAQDLI GNRNMQMMSI EILTLLFTEL
  1501  AKVIESSAKG FPSFISDMLS KCKVQKVILH CLLSSIFSAQ KWHSEKMAGK NLVAVEEGFS
  1561  EDSLINFSED EFDNGSTLQS QLLKVLQRLI VLEHRVMTIP EENETGFDFV VSDLEHISPH
  1621  QPMTSLQYLH AQPITCQGMF LCAVIRALHQ HCACKMHPQW IGLITSTLPY MGKVLQRVVV
  1681  SVTLQLCRNL DNLIQQYKYE TGLSDSRPLW MASIIPPDMI LTLLEGITAI IHYCLLDPTT
  1741  QYHQLLVSVD QKHLFEARSG ILSILHMIMS SVTLLWSILH QADSSEKMTI AASASLTTIN
  1801  LGATKNLRQQ ILELLGPISM NHGVHFMAAI AFVWNERRQN KTTTRTKVIP AASEEQLLLV
  1861  ELVRSISVMR AETVIQTVKE VLKQPPAIAK DKKHLSLEVC MLQFFYAYIQ RIPVPNLVDS
  1921  WASLLILLKD SIQLSLPAPG QFLILGVLNE FIMKNPSLEN KKDQRDLQDV THKIVDAIGA
  1981  IAGSSLEQTT WLRRNLEVKP SPKIMVDGTN LESDVEDMLS PAMETANITP SVYSVHALTL
  2041  LSEVLAHLLD MVFYSDEKER VIPLLVNIMH YVVPYLRNHS AHNAPSYRAC VQLLSSLSGY
  2101  QYTRRAWKKE AFDLFMDPSF FQMDASCVNH WRAIMDNLMT HDKTTFRDLM TRVAVAQSSS
  2161  LNLFANRDVE LEQRAMLLKR LAFAIFSSEI DQYQKYLPDI QERLVESLRL PQVPTLHSQV
  2221  FLFFRVLLLR MSPQHLTSLW PTMITELVQV FLLMEQELTA DEDISRTSGP SVAGLETTYT
  2281  GGNGFSTSYN SQRWLNLYLS ACKFLDLALA LPSENLPQFQ MYRWAFIPEA SDDSGLEVRR
  2341  QGIHQREFKP YVVRLAKLLR KRAKKNPEED NSGRTLGWEP GHLLLTICTV RSMEQLLPFF
  2401  NVLSQVFNSK VTSRCGGHSG SPILYSNAFP NKDMKLENHK PCSSKARQKI EEMVEKDFLE
  2461  GMIKT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DOP1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
22 nTPM

Expression across tissuesHPA

Tissue

  • retina: 22 nTPM
  • skin: 13 nTPM
  • thyroid gland: 13 nTPM
  • testis: 12 nTPM
  • parathyroid gland: 11 nTPM
  • breast: 10 nTPM

Single-cell type

  • epicardial cells: 291 nCPM
  • rod photoreceptor cells: 263 nCPM
  • thyrotrophs: 251 nCPM
  • lactotrophs: 250 nCPM
  • somatotrophs: 246 nCPM
  • sertoli cells: 229 nCPM

Immune cell

  • memory CD8 T-cell: 1.1 nTPM
  • myeloid DC: 0.8 nTPM
  • naive CD4 T-cell: 0.8 nTPM
  • memory B-cell: 0.6 nTPM
  • gdT-cell: 0.5 nTPM
  • eosinophil: 0.4 nTPM

Brain region

  • white matter: 46 nTPM
  • cerebellum: 43 nTPM
  • cerebral cortex: 37 nTPM
  • basal ganglia: 36 nTPM
  • spinal cord: 35 nTPM
  • medulla oblongata: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.25
gnomAD pLI
1
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DOP1A as an antibody target. Whether an autoantibody or antibody against DOP1A could matter depends on whether native DOP1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DOP1A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DOP1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DOP1A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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