Seroatlas · Human Serome Atlas

DOLPP1

Dolichyldiphosphatase 1

Also known as: DOPP1_HUMAN, LSFR2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86YN1
Gene: DOLPP1
Ensembl: ENSG00000167130
Chromosome: 9
Canonical length: 238 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins
Subcellular location: Vesicles,Intermediate filaments

OverviewNCBI Gene

A similar gene has been characterized in mice and encodes dolichyl pyrophosphate (Dol-P-P) phosphatase. This protein dephosphorylates dolichyl pyrophosphate so that it may be re-utilized as a glycosyl carrier lipid by the oligosaccharyltransferase multisubunit complex in the ER. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]

Canonical amino-acid sequenceUniProt

238 residues, UniProt reviewed canonical sequence.

>Q86YN1|DOLPP1
     1  MAADGQCSLP ASWRPVTLTH VEYPAGDLSG HLLAYLSLSP VFVIVGFVTL IIFKRELHTI
    61  SFLGGLALNE GVNWLIKNVI QEPRPCGGPH TAVGTKYGMP SSHSQFMWFF SVYSFLFLYL
   121  RMHQTNNARF LDLLWRHVLS LGLLAVAFLV SYSRVYLLYH TWSQVLYGGI AGGLMAIAWF
   181  IFTQEVLTPL FPRIAAWPVS EFFLIRDTSL IPNVLWFEYT VTRAEARNRQ RKLGTKLQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DOLPP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

duodenum: 25 nTPM
liver: 23 nTPM
small intestine: 21 nTPM
esophagus: 19 nTPM
spinal cord: 15 nTPM
colon: 15 nTPM

Single-cell type

enterocytes: 40 nCPM
platelets: 27 nCPM
esophageal apical cells: 25 nCPM
esophageal suprabasal cells: 24 nCPM
colonocytes: 24 nCPM
cytotrophoblasts: 23 nCPM

Immune cell

MAIT T-cell: 25 nTPM
plasmacytoid DC: 16 nTPM
T-reg: 14 nTPM
memory CD4 T-cell: 13 nTPM
eosinophil: 13 nTPM
memory CD8 T-cell: 13 nTPM

Brain region

white matter: 19 nTPM
pons: 19 nTPM
midbrain: 16 nTPM
thalamus: 16 nTPM
medulla oblongata: 16 nTPM
basal ganglia: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.61
gnomAD pLI: 0.17
gnomAD missense Z: 1.76
DepMap mean gene effect: -0.2
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

dolichyldiphosphatase activity

Cellular components

endoplasmic reticulum membrane

Protein domainsUniProt · Pfam · InterPro

Phosphatidic acid phosphatase type 2/haloperoxidase
Phosphatidic acid phosphatase type 2/haloperoxidase superfamily
PAP2 superfamily
Dolichyldiphosphatase, PAP2 domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DOLPP1 as an antibody target. Whether an autoantibody or antibody against DOLPP1 could matter depends on whether native DOLPP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DOLPP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DOLPP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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