Seroatlas · Human Serome Atlas

DOK6

Docking protein 6

Also known as: DOK5L, DOK6_HUMAN, HsT3226, MGC20785

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PKX4
Gene: DOK6
Ensembl: ENSG00000206052
Chromosome: 18
Canonical length: 331 aa
Protein class: Predicted intracellular proteins
Subcellular location: Focal adhesion sites,Cytosol

OverviewNCBI Gene

DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al., 2004 [PubMed 15286081]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

331 residues, UniProt reviewed canonical sequence.

>Q6PKX4|DOK6
     1  MASNFNDIVK QGYVKIRSRK LGIFRRCWLV FKKASSKGPR RLEKFPDEKA AYFRNFHKVT
    61  ELHNIKNITR LPRETKKHAV AIIFHDETSK TFACESELEA EEWCKHLCME CLGTRLNDIS
   121  LGEPDLLAAG VQREQNERFN VYLMPTPNLD IYGECTMQIT HENIYLWDIH NAKVKLVMWP
   181  LSSLRRYGRD STWFTFESGR MCDTGEGLFT FQTREGEMIY QKVHSATLAI AEQHERLMLE
   241  MEQKARLQTS LTEPMTLSKS ISLPRSAYWH HITRQNSVGE IYSLQGHGFG SSKMSRAQTF
   301  PSYAPEQSEE AQQPLSRSSS YGFSYSSSLI Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DOK6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

retina: 21 nTPM
cerebral cortex: 17 nTPM
amygdala: 15 nTPM
hippocampal formation: 12 nTPM
parathyroid gland: 12 nTPM
midbrain: 8.8 nTPM

Single-cell type

retinal bipolar cells: 1,939 nCPM
brain excitatory neurons: 473 nCPM
brain inhibitory neurons: 370 nCPM
oligodendrocyte progenitor cells: 253 nCPM
other brain neurons: 209 nCPM
pituicytes/fscs: 206 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hippocampal formation: 54 nTPM
cerebral cortex: 47 nTPM
midbrain: 42 nTPM
pons: 40 nTPM
hypothalamus: 38 nTPM
basal ganglia: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.55
gnomAD pLI: 0.16
gnomAD missense Z: 1.35
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell surface receptor protein tyrosine kinase signaling pathway

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of DOK6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

NTRK3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DOK6 as an antibody target. Whether an autoantibody or antibody against DOK6 could matter depends on whether native DOK6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DOK6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DOK6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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