DOK5

Protein identityUniProt · HPA

UniProt accession

Q9P104

Gene

DOK5

Ensembl

ENSG00000101134

Chromosome

20

Canonical length

306 aa

Protein class

Predicted intracellular proteins

Subcellular location

Focal adhesion sites

OverviewNCBI Gene

The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. Unlike other DOK family proteins, this protein does not interact with RASGAP. This protein is up-regulated in patients with systemic sclerosis and is associated with fibrosis induced by insulin-like growth factor binding protein 5. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Canonical amino-acid sequenceUniProt

306 residues, UniProt reviewed canonical sequence.

>Q9P104|DOK5
     1  MASNFNDIVK QGYVRIRSRR LGIYQRCWLV FKKASSKGPK RLEKFSDERA AYFRCYHKVT
    61  ELNNVKNVAR LPKSTKKHAI GIYFNDDTSK TFACESDLEA DEWCKVLQME CVGTRINDIS
   121  LGEPDLLATG VEREQSERFN VYLMPSPNLD VHGECALQIT YEYICLWDVQ NPRVKLISWP
   181  LSALRRYGRD TTWFTFEAGR MCETGEGLFI FQTRDGEAIY QKVHSAALAI AEQHERLLQS
   241  VKNSMLQMKM SERAASLSTM VPLPRSAYWQ HITRQHSTGQ LYRLQDVSSP LKLHRTETFP
   301  AYRSEH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DOK5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.4

Highest tissue expression

43 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.83

gnomAD pLI

0

gnomAD missense Z

0.92

DepMap mean gene effect

0.08

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell surface receptor protein tyrosine kinase signaling pathway
• neuron differentiation
• positive regulation of MAPK cascade
• regulation of neurotrophin TRK receptor signaling pathway

Cellular components

• cytoplasm
• cytosol

Protein domainsUniProt · Pfam · InterPro

• Pleckstrin homology domain
• IRS-type PTB domain
• PH-like domain superfamily
• DOK4/5/6, PH domain
• Docking Protein Family (DOK)
• PTB domain (IRS-1 type)

KeywordsUniProt

• Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of DOK5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• RET