Seroatlas · Human Serome Atlas

DOK3

Docking protein 3

Also known as: DOK3_HUMAN, FLJ22570

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7L591
Gene: DOK3
Ensembl: ENSG00000146094
Chromosome: 5
Canonical length: 496 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cytokinetic bridge,Cytosol

OverviewNCBI Gene

Predicted to be involved in Ras protein signal transduction and cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be located in ficolin-1-rich granule membrane and plasma membrane. Predicted to be active in cytoplasm. Implicated in colorectal adenocarcinoma. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

496 residues, UniProt reviewed canonical sequence.

>Q7L591|DOK3
     1  MTRGARLRSD ARAQLNQLSL DGGTGSGQKG KCEEFPSSLS SVSPGLEAAA LLLAVTMDPL
    61  ETPIKDGILY QQHVKFGKKC WRKVWALLYA GGPSGVARLE SWEVRDGGLG AAGDRSAGPG
   121  RRGERRVIRL ADCVSVLPAD GESCPRDTGA FLLTTTERSH LLAAQHRQAW MGPICQLAFP
   181  GTGEASSGST DAQSPKRGLV PMEENSIYSS WQEVGEFPVV VQRTEAATRC QLKGPALLVL
   241  GPDAIQLREA KGTQALYSWP YHFLRKFGSD KGVFSFEAGR RCHSGEGLFA FSTPCAPDLC
   301  RAVAGAIARQ RERLPELTRP QPCPLPRATS LPSLDTPGEL REMPPGPEPP TSRKMHLAEP
   361  GPQSLPLLLG PEPNDLASGL YASVCKRASG PPGNEHLYEN LCVLEASPTL HGGEPEPHEG
   421  PGSRSPTTSP IYHNGQDLSW PGPANDSTLE AQYRRLLELD QVEGTGRPDP QAGFKAKLVT
   481  LLSRERRKGP APCDRP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DOK3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 88 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 88 nTPM
spleen: 84 nTPM
tonsil: 30 nTPM
lymph node: 29 nTPM
appendix: 29 nTPM
small intestine: 20 nTPM

Single-cell type

neutrophils: 586 nCPM
neutrophil progenitors: 174 nCPM
hofbauer cells: 85 nCPM
monocytes: 83 nCPM
platelets: 70 nCPM
megakaryocytes: 68 nCPM

Immune cell

neutrophil: 134 nTPM
non-classical monocyte: 78 nTPM
classical monocyte: 63 nTPM
intermediate monocyte: 61 nTPM
eosinophil: 57 nTPM
memory B-cell: 37 nTPM

Brain region

pons: 21 nTPM
thalamus: 18 nTPM
medulla oblongata: 18 nTPM
white matter: 14 nTPM
cerebral cortex: 14 nTPM
hypothalamus: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.8
gnomAD pLI: 0
gnomAD missense Z: 0.36
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DOK3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DOK3 as an antibody target. Whether an autoantibody or antibody against DOK3 could matter depends on whether native DOK3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DOK3 is annotated at the cell surface, where native DOK3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label DOK3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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