Seroatlas · Human Serome Atlas

DOK2

Docking protein 2

Also known as: Dok-2, DOK2_HUMAN, p56dok-2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60496
Gene: DOK2
Ensembl: ENSG00000147443
Chromosome: 8
Canonical length: 412 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

412 residues, UniProt reviewed canonical sequence.

>O60496|DOK2
     1  MGDGAVKQGF LYLQQQQTFG KKWRRFGASL YGGSDCALAR LELQEGPEKP RRCEAARKVI
    61  RLSDCLRVAE AGGEASSPRD TSAFFLETKE RLYLLAAPAA ERGDWVQAIC LLAFPGQRKE
   121  LSGPEGKQSR PCMEENELYS SAVTVGPHKE FAVTMRPTEA SERCHLRGSY TLRAGESALE
   181  LWGGPEPGTQ LYDWPYRFLR RFGRDKVTFS FEAGRRCVSG EGNFEFETRQ GNEIFLALEE
   241  AISAQKNAAP ATPQPQPATI PASLPRPDSP YSRPHDSLPP PSPTTPVPAP RPRGQEGEYA
   301  VPFDAVARSL GKNFRGILAV PPQLLADPLY DSIEETLPPR PDHIYDEPEG VAALSLYDSP
   361  QEPRGEAWRR QATADRDPAG LQHVQPAGQD FSASGWQPGT EYDNVVLKKG PK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DOK2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 44 nTPM

Expression across tissuesHPA

Tissue

spleen: 44 nTPM
appendix: 25 nTPM
lymph node: 25 nTPM
lung: 24 nTPM
bone marrow: 18 nTPM
thymus: 15 nTPM

Single-cell type

platelets: 559 nCPM
hofbauer cells: 202 nCPM
kupffer cells: 187 nCPM
cdc: 166 nCPM
nk-cells: 146 nCPM
monocytes: 141 nCPM

Immune cell

eosinophil: 1,569 nTPM
total PBMC: 809 nTPM
intermediate monocyte: 624 nTPM
T-reg: 599 nTPM
non-classical monocyte: 583 nTPM
basophil: 579 nTPM

Brain region

thalamus: 7 nTPM
choroid plexus: 3.5 nTPM
cerebral cortex: 2.8 nTPM
midbrain: 1.5 nTPM
pons: 1.4 nTPM
white matter: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.07
gnomAD pLI: 0
gnomAD missense Z: -0.86
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

transmembrane receptor protein tyrosine kinase adaptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DOK2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DOK2 as an antibody target. Whether an autoantibody or antibody against DOK2 could matter depends on whether native DOK2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DOK2 is annotated at the cell surface, where native DOK2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label DOK2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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