Seroatlas · Human Serome Atlas

DOCK8-AS1

Uncharacterized protein DOCK8-AS1

Also known as: DOAS1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T8R8
Gene: DOCK8-AS1
Canonical length: 295 aa

OverviewNCBI Gene

No narrative summary is available for DOCK8-AS1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

295 residues, UniProt reviewed canonical sequence.

>Q5T8R8|DOCK8-AS1
     1  MRHSVARPTR LPRRLSPFWD PATCKNLEGG AGEVVRGRDP RRLRTSRSTE ILGEDLAGPS
    61  AGAAARPAAP PPQPREPGAP GLRRAPPRTR MDSSGLGPCS EAPLHTSAGL SGRNLRAAGG
   121  VLPVDLERER AALCARQSGH GPPAVRWLLG SRGAESGGLA RRRVAAEHAQ PSANLVCRSA
   181  LETSAFPPSK PKSPRGRVRA RSSDGRLRHP AWRAGSGGRG GRGPSAELAS RYWGRRRALP
   241  GAADLRPKGA RADDRRPLRA GRKLHLPEAA RLPGNVGKSG EPHKAGEVGN HPRDS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DOCK8-AS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.75

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Protein of unknown function DUF5555
Family of unknown function (DUF5555)

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DOCK8-AS1 as an antibody target. Whether an autoantibody or antibody against DOCK8-AS1 could matter depends on whether native DOCK8-AS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DOCK8-AS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DOCK8-AS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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