Seroatlas · Human Serome Atlas

DNTTIP2

Deoxynucleotidyltransferase terminal-interacting protein 2

Also known as: ERBP, HSU15552, TdIF2, TDIF2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5QJE6
Gene: DNTTIP2
Ensembl: ENSG00000067334
Chromosome: 1
Canonical length: 756 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Nucleoli rim,Mitotic chromosome

OverviewNCBI Gene

This gene is thought to be involved in chromatin remodeling and gene transcription. The encoded nuclear protein binds to and enhances the transcriptional activity of the estrogen receptor alpha, and also interacts with terminal deoxynucleotidyltransferase. The expression profile of this gene is a potential biomarker for chronic obstructive pulmonary disease. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

756 residues, UniProt reviewed canonical sequence.

>Q5QJE6|DNTTIP2
     1  MVVTRSARAK ASIQAASAES SGQKSFAANG IQAHPESSTG SDARTTAESQ TTGKQSLIPR
    61  TPKARKRKSR TTGSLPKGTE PSTDGETSEA ESNYSVSEHH DTILRVTRRR QILIACSPVS
   121  SVRKKPKVTP TKESYTEEIV SEAESHVSGI SRIVLPTEKT TGARRSKAKS LTDPSQESHT
   181  EAISDAETSS SDISFSGIAT RRTRSMQRKL KAQTEKKDSK IVPGNEKQIV GTPVNSEDSD
   241  TRQTSHLQAR SLSEINKPNF YNNDFDDDFS HRSSENILTV HEQANVESLK ETKQNCKDLD
   301  EDANGITDEG KEINEKSSQL KNLSELQDTS LQQLVSQRHS TPQNKNAVSV HSNLNSEAVM
   361  KSLTQTFATV EVGRWNNNKK SPIKASDLTK FGDCGGSDDE EESTVISVSE DMNSEGNVDF
   421  ECDTKLYTSA PNTSQGKDNS VLLVLSSDES QQSENSENEE DTLCFVENSG QRESLSGDTG
   481  SLSCDNALFV IDTTPGMSAD KNFYLEEEDK ASEVAIEEEK EEEEDEKSEE DSSDHDENED
   541  EFSDEEDFLN STKAKLLKLT SSSIDPGLSI KQLGGLYINF NADKLQSNKR TLTQIKEKKK
   601  NELLQKAVIT PDFEKNHCVP PYSESKYQLQ KKRRKERQKT AGDGWFGMKA PEMTNELKND
   661  LKALKMRASM DPKRFYKKND RDGFPKYFQI GTIVDNPADF YHSRIPKKQR KRTIVEELLA
   721  DSEFRRYNRR KYSEIMAEKA ANAAGKKFRK KKKFRN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNTTIP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 14 nTPM
skeletal muscle: 8.6 nTPM
urinary bladder: 6 nTPM
epididymis: 5.7 nTPM
skin: 5.1 nTPM
lymph node: 5 nTPM

Single-cell type

neutrophils: 159 nCPM
oocytes: 147 nCPM
endometrial secretory cells: 125 nCPM
monocytes: 122 nCPM
endometrial glandular cells: 117 nCPM
alveolar cells type 1: 109 nCPM

Immune cell

eosinophil: 12 nTPM
basophil: 9.8 nTPM
NK-cell: 9.6 nTPM
naive B-cell: 8.5 nTPM
non-classical monocyte: 8.5 nTPM
intermediate monocyte: 8.4 nTPM

Brain region

cerebellum: 28 nTPM
cerebral cortex: 21 nTPM
white matter: 21 nTPM
hypothalamus: 20 nTPM
choroid plexus: 20 nTPM
basal ganglia: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.9
gnomAD pLI: 0
gnomAD missense Z: 0.57
DepMap mean gene effect: -0.77
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Fcf2 pre-rRNA processing, C-terminal
Fcf2/DNTTIP2
Fcf2 pre-rRNA processing

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DNTTIP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DNTTIP2 as an antibody target. Whether an autoantibody or antibody against DNTTIP2 could matter depends on whether native DNTTIP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DNTTIP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DNTTIP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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