Seroatlas · Human Serome Atlas

DNPH1

5-hydroxymethyl-dUMP N-hydrolase

Also known as: C6orf108, dJ330M21.3, DNPH1_HUMAN, rcl

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43598
Gene: DNPH1
Ensembl: ENSG00000112667
Chromosome: 6
Canonical length: 174 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene was identified on the basis of its stimulation by c-Myc protein. The latter is a transcription factor that participates in the regulation of cell proliferation, differentiation, and apoptosis. The exact function of this gene is not known but studies in rat suggest a role in cellular proliferation and c-Myc-mediated transformation. Two alternative transcripts encoding different proteins have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

174 residues, UniProt reviewed canonical sequence.

>O43598|DNPH1
     1  MAAAMVPGRS ESWERGEPGR PALYFCGSIR GGREDRTLYE RIVSRLRRFG TVLTEHVAAA
    61  ELGARGEEAA GGDRLIHEQD LEWLQQADVV VAEVTQPSLG VGYELGRAVA FNKRILCLFR
   121  PQSGRVLSAM IRGAADGSRF QVWDYEEGEV EALLDRYFEA DPPGQVAASP DPTT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNPH1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 181 nTPM

Expression across tissuesHPA

Tissue

kidney: 181 nTPM
liver: 133 nTPM
choroid plexus: 122 nTPM
basal ganglia: 110 nTPM
adrenal gland: 100 nTPM
amygdala: 99 nTPM

Single-cell type

enterocytes: 713 nCPM
hofbauer cells: 433 nCPM
epididymal efferent duct ciliated cells: 411 nCPM
fallopian tube ciliated cells: 392 nCPM
epididymal efferent duct absorptive cells: 371 nCPM
respiratory ciliated cells: 296 nCPM

Immune cell

T-reg: 271 nTPM
intermediate monocyte: 238 nTPM
memory B-cell: 221 nTPM
naive B-cell: 196 nTPM
myeloid DC: 179 nTPM
non-classical monocyte: 178 nTPM

Brain region

choroid plexus: 85 nTPM
thalamus: 43 nTPM
hypothalamus: 42 nTPM
basal ganglia: 39 nTPM
spinal cord: 36 nTPM
amygdala: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.26
gnomAD pLI: 0.03
gnomAD missense Z: 0.64
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Nucleoside 2-deoxyribosyltransferase
2-deoxynucleoside 5-phosphate N-hydrolase 1, DNPH1
2'-Deoxynucleoside 5'-phosphate N-hydrolase
Nucleoside 2-deoxyribosyltransferase

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DNPH1 as an antibody target. Whether an autoantibody or antibody against DNPH1 could matter depends on whether native DNPH1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DNPH1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DNPH1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...