Seroatlas · Human Serome Atlas

DNM1P46

Putative GED domain-containing protein DNM1P46

Also known as: DMP46_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZS02
Gene: DNM1P46
Canonical length: 220 aa

OverviewNCBI Gene

No narrative summary is available for DNM1P46 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

220 residues, UniProt reviewed canonical sequence.

>Q6ZS02|DNM1P46
     1  MLQLAGVSNS TCGGVRNVSV ETRNVKPQGK DSKAEENGSH SFMHSMDPQL ERQMETTQNL
    61  VDSYMAIVNK TVWDLMVGAK PKTTMHIMIY NVHAPPHGDQ GVHLLGAAVQ PALAWEREDT
   121  HGGVGRVGTA ARRDAASQSC CPTCTRLGTR RHSWRSRQSR HSGATRLAWE EIDTPGGVGR
   181  AGTAARRDSR GNEKTLLEES AEQADQGVHL LGAAVQPALA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNM1P46 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

GTPase effector domain

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DNM1P46 as an antibody target. Whether an autoantibody or antibody against DNM1P46 could matter depends on whether native DNM1P46 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DNM1P46 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DNM1P46 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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