Seroatlas · Human Serome Atlas

DNASE2B

Deoxyribonuclease-2-beta

Also known as: DLAD, DNS2B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WZ79
Gene: DNASE2B
Ensembl: ENSG00000137976
Chromosome: 1
Canonical length: 361 aa
Protein class: Enzymes, Predicted intracellular proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

The protein encoded by this gene shares considerable sequence similarity to, and is structurally related to DNase II. The latter is a well characterized endonuclease that catalyzes DNA hydrolysis in the absence of divalent cations at acidic pH. Unlike DNase II which is ubiquitously expressed, expression of this gene product is restricted to the salivary gland and lungs. The gene has been localized to chromosome 1p22.3 adjacent (and in opposite orientation) to the uricase pseudogene. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

361 residues, UniProt reviewed canonical sequence.

>Q8WZ79|DNASE2B
     1  MKQKMMARLL RTSFALLFLG LFGVLGAATI SCRNEEGKAV DWFTFYKLPK RQNKESGETG
    61  LEYLYLDSTT RSWRKSEQLM NDTKSVLGRT LQQLYEAYAS KSNNTAYLIY NDGVPKPVNY
   121  SRKYGHTKGL LLWNRVQGFW LIHSIPQFPP IPEEGYDYPP TGRRNGQSGI CITFKYNQYE
   181  AIDSQLLVCN PNVYSCSIPA TFHQELIHMP QLCTRASSSE IPGRLLTTLQ SAQGQKFLHF
   241  AKSDSFLDDI FAAWMAQRLK THLLTETWQR KRQELPSNCS LPYHVYNIKA IKLSRHSYFS
   301  SYQDHAKWCI SQKGTKNRWT CIGDLNRSPH QAFRSGGFIC TQNWQIYQAF QGLVLYYESC
   361  K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNASE2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 160 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 160 nTPM
prostate: 6.3 nTPM
lung: 2.3 nTPM
skeletal muscle: 1.5 nTPM
basal ganglia: 1 nTPM
spinal cord: 1 nTPM

Single-cell type

salivary acinar cells: 98 nCPM
salivary myoepithelial cells: 52 nCPM
lacrimal acinar cells: 34 nCPM
macrophages: 9.9 nCPM
neutrophils: 6.5 nCPM
prostatic glandular cells: 6.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 1.7 nTPM
white matter: 1.4 nTPM
basal ganglia: 0.9 nTPM
medulla oblongata: 0.9 nTPM
cerebral cortex: 0.6 nTPM
pons: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.63
gnomAD pLI: 0
gnomAD missense Z: 0.16
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

apoptotic DNA fragmentation

Molecular functions

deoxyribonuclease II activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DNASE2B as an antibody target. Whether an autoantibody or antibody against DNASE2B could matter depends on whether native DNASE2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DNASE2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DNASE2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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